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In this month’s “Hot Topic,” Robin Patel, M.D., discusses the FilmArray meningitis/encephalitis (ME) panel, describing the panel, her experience with it, and an algorithm for its use.

Mayo Clinic laboratory experts share six case studies in this month’s “PathWays” post and are challenging you to test your bone and soft tissue, surgical, clinical, genitourinary pathology, hematopathology and laboratory genetics and genomics knowledge. Review the cases, take the quizzes, and learn how the correct diagnoses were made.

Antibodies to aquaporin-4 and myelin oligodendrocyte glycoprotein (MOG) are recently described biomarkers seen in a subset of atypical optic neuritis which have revolutionized our understanding of the condition. In this “Hot Topic,” my colleague, Dr. John Chen, will review these advances and how they impact the clinical care of our patients with optic neuritis.

The standard test for the diagnosis of narcolepsy is the multiple sleep latency test (MSLT). The MSLT is a complex test to perform as well as to interpret. The orexin-A/hypocretin-1 test is a sensitive and specific alternative to the MSLT to diagnose type 1 narcolepsy.

The presence NTRK gene fusions is one of the eligibility requirements for the recently FDA-approved therapy Vitrakvi (larotrectinib), a therapy indicated in adult and pediatric patients with solid tumors regardless of the type of tumor. NTRK gene fusions have been described in many cancers at various frequencies including common cancers such as lung, thyroid, and colorectal cancers.

Mayo Clinic laboratory experts share six case studies in this month’s “PathWays” post and are challenging you to test your cytopathology, anatomic and clinical, and molecular genetic pathology knowledge. Review the cases, take the quizzes, and learn how the correct diagnoses were made.

Mayo Clinic laboratory experts share five case studies in this month’s “PathWays” post and are challenging you to test your anatomic pathology, biochemical genetics, anatomic and clinical pathology, and special coagulation knowledge. Review the cases, take the quizzes, and learn how the correct diagnoses were made.

In this month’s “Hot Topic,” Julia Lehman, M.D., will discuss a rare and potentially fatal mucocutaneous blistering disease that is often associated with an underlying malignancy, called paraneoplastic pemphigus. She will also discuss the specialized tissue and serum testing that is required to establish the diagnosis.

In this month’s “Hot Topic,” Rajiv Pruthi, M.B.B.S., will discuss different types of hemophilia along with their pathologic basis. He will also cover various types of factor assays such as one stage and chromogenic factor assays for diagnosis and their role in management of hemophilia.

In this month’s “Hot Topic,” Brad Karon, M.D., Ph.D., will cover the need and evidence behind following the order of draw recommendations for routine blood collection. Specifically, does evidence demonstrate a need to collect serum tubes before either potassium EDTA or citrate tubes?

This “Specialty Testing” webinar will discuss the diagnosis, pathological understanding, and current best treatment options for necrotizing autoimmune myopathy.

In this month’s “Hot Topic,” Robin Patel, M.D., discusses how matrix-assisted laser desorption ionization time of flight (MALDI TOF) mass spectrometry works for bacterial identification, including the strengths and limitations of this technology. She also covers Mayo Clinic’s experience with the technology in the clinical laboratory.

Mayo Clinic laboratory experts share three case studies in this month’s “PathWays” post and are challenging you to test your anatomic and clinical pathology, laboratory genetics and genomics, and pathology and cytology knowledge. Review the cases, take the quizzes, and learn how the correct diagnoses were made.