Non-invasive testing options
to optimize compliance.

Diagnosis and Monitoring of Exocrine Pancreatic Insufficiency (EPI)

Stool testing is a critical component of diagnosing EPI and Mayo Clinic Laboratories offers multiple tests to help clinicians in their work-up of these patients.

While a 48- or 72-hour stool fecal fat test is extremely useful for evaluating for the presence of steatorrhea, which indicates malabsorption disorders like EPI, patients often find this cumbersome and difficult to tolerate, which greatly impacts compliance.

To address this issue, Mayo Clinic Laboratories also offers pancreatic elastase testing, which is an alternative approach to fecal fat testing that patients may find more convenient due to it only requiring a single stool collection.

Measuring Pancreatic Elastase (PE) in stool is representative of pancreatic enzyme production and patients with EPI may have reduced concentrations of PE in feces.

Which test should I order?

FATF | Fat, Feces

Genetic Testing to confirm a suspected clinical diagnosis of familial or hereditary pancreatitis

Hereditary pancreatitis (HP) is defined as 2 or more individuals in a family affected with pancreatitis involving at least 2 generations. Mutations in several genes, includingPRSS1, CFTR, CTRC, and SPINK1 have demonstrated genetic susceptibility to chronic pancreatitis. 

Genetic testing can confirm suspected clinical diagnosis of familial or hereditary pancreatitis in patients with chronic pancreatitis, identify gene mutations contributing to pancreatitis in an individual family, and allow for predictive and diagnostic testing in family members.

Learn more about how to order these evaluations at your institution.