Bleeding disorders

The right test at the right time

Bleeding disorders are defined as a familial or acquired disorder that causes the blood to lack certain clotting factors. While most people are familiar with hemophilia, a more recognized inherited disorder, patients also can be affected by other bleeding disorders, including platelet disorders or von Willebrand disease. Whether a disorder is inherited or acquired, Mayo Clinic’s Special Coagulation Laboratory offers a number of algorithmic approaches to meet your testing needs. Testing for a number of factor deficiencies, von Willebrand profiles with high resolution multimer analysis, platelet function testing, and inhibitor analysis are all offered by our expert team. Our algorithms are thoughtfully crafted through collaboration with clinicians, laboratorians, and genetic counselors and aim to provide the best patient care while promoting proper test utilization. It’s about the right test, for your patient, at the right time. 

Key testing

Coagulation factor inhibitor profiles

Chromogenic Factor VIII and IX Assays: Impact on diagnosis and management of hemophilia

Congenital bleeding disorders may be categorized into coagulation factor deficiencies and platelet disorders. The most common coagulation factor deficiency-related bleeding disorder is von Willebrand disease, a deficiency of von Willebrand factor.

Case study: Reducing costs through an algorithmic approach to testing

Our algorithmic approach to testing consistently yields cost-saving benefits for laboratories. On average per 100 patients, von Willebrand profiles were ordered for each patient to confirm diagnosis. Using an algorithmic approach to testing, only 30 patients went on to receive an additional multimer test for further confirmation. When an algorithmic approach is not utilized, these additional tests are performed for 100% of von Willebrand test orders. For these patients, our algorithmic approach saved up to $19,500.

Learn more about how to order this evaluation at your institution.