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Thrombosis Disorders

An algorithmic approach to provide the best patient care

Thrombophilia is defined as an acquired or familial disorder associated with thrombosis. The clinical presentation of an underlying thrombophilia predominantly includes venous thromboembolism (deep vein thrombosis, pulmonary embolism, superficial vein thrombosis). Other manifestations that have been linked to thrombophilia include recurrent miscarriage and complications of pregnancy (eg, severe preeclampsia, abruptio placentae, intrauterine growth restriction, stillbirth).

Whether acquired or inherited the underlying causes of thrombophilia can be very diverse. Mayo Clinic’s Special Coagulation Laboratory offers a number of algorithmic approaches to thrombophilia testing. Our algorithms are thoughtfully crafted through collaboration with clinicians, laboratorians, and genetic counselors and aim to provide the best patient care while promoting proper test utilization. It’s about the right test, for your patient, at the right time.

Which test should I order?


Test Utilization Practices for Venous Thromboembolism: A Model of Cost Savings and Efficiency at Mayo Clinic

A recent Mayo Clinic study has found that many U.S. health care providers are habitually ordering a mostly unnecessary, and quite expensive, genetic test to identify a patient’s hereditary risk of venous thromboembolism (VTE).

Learn more about how to order this evaluation at your institution.