Simplifying a complex
medical journey

Advancing patient care with
superior testing

As a pioneer in the field, Mayo Clinic plays an integral role by developing new tests to help align patients with new therapies for plasma cell disorders. Our algorithmic approach ensures that the right tests are ordered at the right time, and that health care providers get clinically actionable answers for their patients faster. And testing with Mayo Clinic means 24/7 access to our physician and laboratory experts, who are leaders in their fields.

With you every step of the way


A groundbreaking method to accurately identify
monoclonal proteins and determine risk of progression

Diagnosis and risk stratification

A simplified approach to risk stratification and
diagnosis using the Mayo Stratification for
Myeloma and Risk-Adapted Therapy (mSMART)


Accurate monitoring of patients to determine
response to therapy and risk of relapse

Breaking down the facts

When a patient presents with a monoclonal protein (M-protein) disorder, the answer is not always multiple myeloma. From the more common diagnosis of monoclonal gammopathy of undetermined significance (MGUS), to rarer findings such as amyloid light-chain (AL) amyloidosis or POEMS syndrome, it is becoming more recognized that plasma cell neoplasms are not just one disease, and they are characterized by marked protein, cytogenetic, molecular, and proliferative heterogeneity. Clinicians are increasingly challenged to provide answers in this rapidly changing environment. Advances in testing methodologies, novel therapies, and individualized treatment regimens continually add to the complexity of helping patients. Whether you’re screening, diagnosing, or monitoring patients, we offer leading edge testing while keeping patient care local.

How an ex-NFL linebacker overcame his greatest opponent, amyloidosis

Matt Millen, ex-pro NFL player, who played on four Super Bowl-winning teams underwent a nearly six-year medical journey in search for answers. Finally, he was diagnosed with amyloidosis using a new testing methodology at Mayo Clinic.

Additional resources

By Mayo Clinic Laboratories • March 16, 2021
By MCL Education • October 12, 2020
By Suzanne Ferguson • September 10, 2020
By Christoph Bahn • March 10, 2020
By Alyssa Frank • January 18, 2020