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Simplifying a complex
medical journey.

Advancing patient care with
superior testing.

As a pioneer in the field, Mayo Clinic plays an integral role by developing new tests to help align patients with new therapies for plasma cell disorders. Our algorithmic approach ensures that the right tests are ordered at the right time, and that health care providers get clinically actionable answers for their patients faster. And testing with Mayo Clinic means 24/7 access to our physician and laboratory experts, who are leaders in their fields

With you Every Step of the Way


A groundbreaking method to accurately identify
monoclonal proteins and determine risk of progression.

Diagnosis and Risk Stratification

A simplified approach to risk stratification and
diagnosis using the Mayo Stratification for
Myeloma and Risk-Adapted Therapy (mSMART).


Accurate monitoring of patients to determine
response to therapy and risk of relapse.

Breaking down the facts

When a patient presents with a monoclonal protein (M protein) disorder, the answer is not always multiple myeloma. From the more common diagnosis of monoclonal gammopathy of undetermined significance (MGUS), to rarer findings such as AL amyloidosis or POEMS syndrome, plasma cell neoplasms are increasingly recognized as more than one disease and characterized by marked protein, cytogenetic, molecular, and proliferative heterogeneity. Clinicians are increasingly challenged to provide answers in this rapidly changing environment. Advances in testing methodologies, novel therapies, and individualized treatment regimens continually add to the complexity of treating patients. Whether you’re screening, diagnosing, or monitoring patients, we offer leading-edge testing while keeping patient care local.

How an Ex-NFL Linebacker Overcame his Greatest Opponent, Amylodosis

Matt Millen, ex-pro NFL player, who played on four Super Bowl-winning teams underwent a nearly six-year medical journey in search for answers. Finally, he was diagnosed with amyloidosis using a new testing methodology at Mayo Clinic.

Additional Resources

Multiple myeloma testing

In this "Hot Topic," Dragan Jevremovic, M.D., Ph.D., reviews the diagnostic criteria for multiple myeloma and discusses the laboratory tests, including the use of next-generation sequencing, that can be used to help diagnose and manage patients with this disease.

Genetic testing to enhance multiple myeloma treatment

Mayo Clinic is making significant advances with an individualized medicine approach. In recent years, Mayo researchers and others have uncovered a wealth of information about the genetic mutations that help multiple myeloma cells survive and multiply. Now, Mayo Clinic has translated those discoveries into clinical testing to personalize care.

Advancing multiple myeloma diagnosis

The standard laboratory test to diagnose multiple myeloma dates back to the Eisenhower administration. Research at Mayo Clinic spearheaded by David Murray, M.D., Ph.D. (PATH ’10), and fueled by his experience as an industrial chemist has led to a new assay to screen and diagnose the disease.