Amyloidosis

A personalized approach for superior sensitivity and accuracy

Our amyloid protein identification methodology is considered the gold standard because of the high sensitivity and accuracy with which it types amyloid proteins in paraffin-embedded specimens. By combining focused laser microdissection (LMD) of Congo red-positive amyloid plaques with the analytical power of liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomic analysis, LC-MS/MS identifies the amyloid type with 100% specificity and 98% sensitivity.

Amyloidosis Test menu

Amyloidosis

Amyloidosis is the buildup of abnormal misfolded proteins in the organs. The disease can be systemic and life-threatening, frequently affecting the kidneys, heart, or other vital organs. At least 36 different proteins cause amyloidosis, and the underlying pathogenesis of each type is unique.

Key testing

Advantages

  • Provides a definitive identification of amyloid proteins, with 100% specificity and 98% sensitivity.
  • Relies on laser microdissection of Congo red-positive amyloid deposits followed by analysis by LC-MS/MS to accurately determine the identity of the proteins that constitute the amyloid.
  • Unambiguously identifies all amyloid types in a single assay.

Highlights

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