Anti-MAG (Myelin Associated Glycoprotein) Neuropathy
Pinpointing diagnosis with precision testing
The presence of MAG antibodies is often linked to a rare demyelinating neuropathy with poor treatment response known as distal acquired demyelinating sensory (DADS) neuropathy. In some cases, reaching correct diagnosis through clinical and electrophysiological evaluation alone can be difficult due to overlapping features, or when patient evaluation occurs later in the disease course. Incorporating MAG antibody testing into the diagnostic workup can help identify the correct diagnosis and exclude patients with treatable immune-mediated neuropathies.
A Test in Focus
John Mills, Ph.D., explains Mayo Clinic Laboratories’ approach to MAG antibody testing. The ELISA-based assay uses higher reference ranges and human MAG antigen to detect MAG antibodies, which are associated with a rare, hard-to-treat condition known as DADS neuropathy.
The role of MASS-FIX
Although most anti-MAG neuropathy cases have an associated IgM M-protein, in some cases testing using traditional approaches (such as serum electrophoresis and immunofixation) can be negative, which delays IgM M-protein discovery. MASS-FIX is a pioneering mass spectrometry assay that enables enhanced sensitivity and specificity compared to traditional approaches when looking for the presence of M-proteins in the blood.
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