Mayo Clinic Laboratories offers a profile that can assist in the diagnosis of multiple sclerosis (MS) by measuring kappa immunoglobin light chains in cerebral spinal fluid (KCSF) with a reflex, if positive, to oligoclonal banding. Propelled by Mayo Clinic-led studies into the presence of kappa IgG biomarkers in the spinal fluid of patients with MS, the assay has been optimized for peak antibody detection. This increased sensitivity delivers precision results that set patients on the correct diagnostic pathway.
30%-67% OF PATIENTS REFERRED TO MS SUBSPECIALTY CENTERS WITH SUSPECTED MS DIAGNOSIS ULTIMATELY DETERMINED NOT TO HAVE MS1
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For patients suspected of having multiple sclerosis, testing for neurofilament light chain (NfL), a generic marker of neurodegeneration, can confirm a neurodegenerative disease process. Propelled by Mayo Clinic-led research, Mayo Clinic Laboratories has implemented a first-in-class assay to test for elevated levels of NfL in the blood. Positive test results not only confirm neuronal damage but can offer insights on disease severity, progression, and prognosis to guide therapeutic decision-making.
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