Clarification for a
Comprehensive genetic analysis
Sarcomas are malignant tumors that arise in the bone and soft tissue. With numerous subtypes of sarcoma that can have overlapping histological, immunophenotypic, and clinical features, diagnosis can be extremely challenging. This challenge increases when rare subtypes are encountered for which most pathologists will have little experience. Using only histological and immunophenotypic features can lead to a high rate of inaccurate diagnoses. Published data indicates a substantial number of patients have discordant diagnoses between referring institutions and specialty centers. Supplementing the histologic diagnosis with genetic testing can improve diagnostic accuracy and overall patient management.
Five cases studies that highlight several teaching points and walk through the testing ordered for each patient type.