Mayo Clinic Laboratories > Oncology > Sarcoma

Sarcoma

Clarification for a challenging diagnosis

With numerous subtypes of sarcoma that have overlapping histological, immunophenotypic, and clinical features, diagnosis can be extremely challenging. This challenge increases when rare subtypes are encountered for which most pathologists will have little experience. Since using only histological and immunophenotypic features can lead to a high rate of inaccurate diagnoses, we recommend supplementing histologic diagnosis with genetic testing to improve diagnostic accuracy and overall patient management.

Our full suite of sarcoma testing, including pathology consultation, can clarify diagnosis and set patients on the best treatment path.

Next-generation sequencing Next-generation sequencing
Next-generation sequencing

Mayo Clinic Laboratories’ comprehensive next-generation sequencing sarcoma fusion panel includes 169 genes and assesses mutations and fusions described in more than 50 types of soft tissue, bone, and other mesenchymal tumors.

Single-gene testing Single-gene testing
Single-gene testing

In cases where comprehensive next-generation sequencing analysis cannot be performed or the diagnosis is highly suspect, we offer numerous single-gene fluorescence in situ hybridization (FISH) tests to identify common genetic rearrangements.

Bone and soft tissue pathology Bone and soft tissue pathology
Bone and soft tissue pathology

For sarcoma cases needing an added level of support, our second-opinion pathology consultations are conducted by a team of pathologists who are experts in bone and soft tissue pathology.

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