Providing answers
to guide treatment.

Diagnose complex cases.

Mayo Clinic Laboratories’ is integrated with the Renal Biopsy Laboratory in the Department of Laboratory Medicine and Pathology at Mayo Clinic. Board-certified pathologist have a special interest in non-neoplastic disease of the kidney and are available to support your clinical decisions.

By The Numbers


Number of analyzed biopsies and delivered answers in our Renal Biopsy Laboratory per year.


Mayo Clinic renal biopsy technicians and renal pathologist are available for STAT diagnosis.

Optimal interpretation

To ensure diagnostic accuracy and thoroughness, a Mayo Clinic renal pathologist evaluates kidney biopsy specimens by light microscopy, immunofluorescence, electron microscopy, and when indicated, by ancillary techniques (such as pronase immunofluorescence, IgG subtype staining, immunohistochemistry, mass spectrometry, etc.). The pathologic findings are reported based on current diagnostic standards established by the Renal Pathology Society, Banff Conferences, and International Kidney and Monoclonal Gammopathy Research Group.

Comprehensive results

All results will include the following information-based standards for the diagnostic evaluation and reporting of non-neoplastic renal disease

  • Clinical History
  • Gross description of biopsy specimen
  • Light microscopy results
  • Immunofluorescence microscopy results
  • Electron microscopy results
  • Diagnostic comments
  • Additional stains, performed on a case-by-case basis

Optimum analysis stems from proper specimen collection

To increase accuracy and improve turnaround time, refer to the renal biopsy patient information and renal biopsy procedure for handling tissue on the LM IF and EM forms.


RPCWT | Renal Pathology Consultation, Wet Tissue

Clinical Utility

• Diagnoses kidney disease that cannot otherwise be definitively diagnosed.

• Aids clinicians in developing a treatment plan based on the pathology identified.

• Aids clinicians in determining the extent of kidney damage or disease state.

When Should I Use the Consultation?

• Evaluating and managing patients with medical kidney disease.

• Following the progression of known renal disease or response to therapy.

• Determining the cause of dysfunction in the transplanted kidney (allograft).

Complex renal biopsy considerations

  • Assess for rejection, infection, recurrent native disease, de novo disease, etc.
  • To identify the etiology of:
    • Acute Kidney Injury
    • Chronic Kidney Disease
    • Nephrotic Syndrome
    • Nephritic Syndrome
    • Proteinuria
    • Isolated hematuria

Learn more about how to order these evaluations at your institution.