Increase understanding

Define metabolic traits

To optimize patient care, our kidney stone services will describe the metabolic composition of stones. Mayo Clinic Laboratories’ comprehensive approach supports your practice with accurate interpretation to help you make accurate and helpful clinical decisions.

Clarity, not questions

Comprehensive analysis of test results by our experts, who apply the most up-to-date scientific data, enables clear answers that illuminate patients’ stone composition. Our detailed report interpretations include patient-specific therapeutic and diagnostic comments that provide a deeper understanding of a patient’s condition to help guide treatment.

Sample report

Key testing

SUP24 | Supersaturation Profile, 24 Hour, Urine

  • Identifies urinary supersaturations that increase the risk of specific types of stones.
  • Identifies specific urine abnormalities that increase overall saturation.
  • Aids accurate treatment plan development.
  • Monitors treatment effectiveness.
  • Aids in reducing stone recurrences.

SUPRA | Supersaturation Profile, Random, Urine

  • Particularly helpful for pediatric patients when 24-hour stone collection is not possible.
  • Identifies urinary supersaturations that increase the risk of specific types of stones.
  • Identifies specific urine abnormalities that increase overall saturation.
  • Aids accurate treatment plan development.
  • Monitors treatment effectiveness.
  • Aids in reducing stone recurrences.

When to consider testing

  • In patients with new or recurrent histories of urinary stones.
  • In patients with known risk factors for stones.
  • When a stone is unavailable for analysis to determine the most likely type.
  • In conjunction with a kidney stone analysis to determine patient-specific risk factors.

Test ordering pattern recommendations 

  • Order two tests to assess risk factors.
  • Repeat testing 4-6 weeks after the start of a treatment plan to determine effectiveness and modify accordingly.
  • Test annually for further evaluation.

Supersaturation analytes evaluated

  • Ammonium
  • Calcium
  • Chloride
  • Citrate excretion
  • Creatinine
  • Magnesium
  • Osmolality
  • Oxalate
  • pH
  • Phosphorus
  • Potassium
  • Sodium
  • Sulfate
  • Urea nitrogen
  • Uric acid

Learn more about how to order these evaluations at your institution.