Targeted screening for detection and monitoring

Accurately detect benzodiazepine use

Benzodiazepines represent a large family of medications used to treat a wide range of disorders, from anxiety to seizures. They also are used in pain management. With a high risk for abuse and diversion, professional practice guidelines recommend compliance monitoring for these medications using urine drug tests. However, traditional benzodiazepine immunoassays suffer from a lack of cross-reactivity with many benzodiazepines.

Mayo Clinic Laboratories now offers a targeted, high-resolution mass spectrometry screening assay that will identify 27 different benzodiazepines and metabolites in the urine, and reduces the need for additional confirmation assays. Results of this assay will enable clinicians to accurately detect recent benzodiazepine use and effectively monitor treatment compliance.

Targeted screening for enhanced detection

TBSU | Targeted Benzodiazepine Screen, Random, Urine

Ensure adherence to federal and state regulations by:

  • Monitoring compliance of patients prescribed benzodiazepine(s).
  • Identifying potential illicit benzodiazepine use

Substances assessed include, but are not limited to:

  • Alprazolam (Xanax)
  • Clobazam (Onfi)
  • Clonazepam (Klonopin)
  • Chlordiazepoxide (Librium)
  • Diazepam (Valium)
  • Flunitrazepam (Rohypnol)
  • Lorazepam (Ativan)
  • Midazolam (Versed)
  • Oxazepam (Serax)
  • Prazepam (Centrax)
  • Temazepam (Restoril)
  • Triazolam (Halcion)

Comprehensive monitoring profiles

New high-resolution targeted benzodiazepine screen

Paul Jannetto, Ph.D., highlights Mayo Clinic’s new targeted benzodiazepine assay, and discusses the advantages and limitations of various urine screening assays and quantitative confirmatory testing to determine compliance to benzodiazepine therapy. 

Eliminate doubt

Analysis of urine drug testing results by our experts, who apply the most up-to-date scientific data, enables further transparency and clear answers that illuminate patients’ drug use.

Pharmacokinetics of CNS depressants

Substances that can interfere with simple (immunoassay) CNS depressants screening results

Learn more about how to order these tests at your institution.