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Accurately detect opioid use.

Opioids represent a large class of medications commonly used to relieve acute and chronic pain, or to help manage opioid abuse and dependence. These medications can produce physical and psychological dependence and have a high risk for abuse and diversion. As a result, many professional practice guidelines recommend compliance testing in patients who are prescribed these medications.

Mayo Clinic Laboratories now offers a targeted, high-resolution mass spectrometry screening assay that does not hydrolyze the urine sample, allowing for both the parent and metabolites of 33 different opioids to be detected. Results of this assay will enable clinicians to accurately detect opioid use and effectively monitor treatment compliance. 

TOSU | Targeted Opioid Screen, Random, Urine

Ensure adherence to federal and state regulations by:

  • Monitoring compliance of patients prescribed opioid(s).
  • Identifying potential illicit opioid use

Drugs detected in the high-resolution targeted opioid screen.


New high-resolution targeted opioid screen

Paul Jannetto, Ph.D., highlights Mayo Clinic’s new targeted opioid assay, and discusses the advantages and limitations of various urine screening assays and quantitative confirmatory testing to determine compliance to opioid therapy. 

Learn more about how to order these tests at your institution.

Additional resources