Mayo Clinic Laboratories > Therapeutics > Controlled substance monitoring > Targeted mass spectrometry screening

Targeted MASS SPECtrometry screening

Precision insights to assess therapy and identify abuse

We offer advanced mass spectrometry screening assays available to order individually. These assays detect a wide range of substances including the parent drug and metabolites of 27 benzodiazepines, 33 opioids (including fentanyl, heroin, and oxycodone), and 11 stimulants (such as amphetamines and MDMA), providing more accurate results than immunoassays. These tests help clinicians detect illegal use, ensure prescribing compliance, and detect spiked specimens, with interpretative comments included for clearer clinical insights.

Targeted MASS SPECTrOMETRY screening test menu

Targeted mass spectrometry screening Targeted mass spectrometry screening

Targeted mass spectrometry screening

Key testing

  • TBSU | Targeted Benzodiazepine Screen, Random, Urine
    • Uses high-resolution accurate mass spectrometry to identify 27 different benzodiazepines and metabolites (including clobazam, zolpidem, and all commonly prescribed benzodiazepines) where immunoassays are not adequate.
    • Detects spiked specimens.
    • Results reported with interpretative comments.
  • TOSU | Targeted Opioid Screen, Random, Urine
    • Uses high-resolution accurate mass spectrometry to identify 33 different opioids and metabolites (including buprenorphine, codeine, fentanyl, heroin, hydrocodone, hydromorphone, methadone, morphine, naloxone, oxycodone, tapentadol, and tramadol) where immunoassays are not adequate.
    • Detects spiked specimens.
    • Results reported with interpretative comments.
  • TSPU | Targeted Stimulant Screen, Random, Urine
    • Uses high-resolution accurate mass spectrometry to identify 11 different stimulants and metabolites (including amphetamines, methylphenidate, ritalinic acid, 3,4-methylenedioxymethamphetamine [MDMA], and PCP) where immunoassays are not adequate.
    • Detects spiked specimens.
    • Results reported with interpretative comments.
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