Monitor use and support recovery through direct ethanol biomarker testing

As opposed to the limited sensitivity and specificity of indirect ethanol biomarker testing, direct biomarker testing offers heightened sensitivity and specificity to identify alcohol use disorder (AUD), which is estimated to affect 300 million people worldwide.1

Our menu of direct ethanol biomarker testing accurately assesses alcohol use and AUD. This methodology enables detection of even small amounts of ethanol eliminated via non-oxidative pathways into ethyl glucuronide (EtG), ethyl sulfate (EtS), and phosphatidylethanol (PEth).2 Because these direct alcohol biomarkers have a longer half-life and extended detection window, alcohol consumption over a period of several days can be more accurately assessed.

Ethanol test menu

More information

Additional benefits of biomarker testing include:

  • Improved analysis of the specific role alcohol plays on an individual’s health.3
  • Test results clarify actual amounts of recent consumption, which, combined with questionnaires, can support initiating clinical interventions.

Optimized testing

Because hazardous drinking practices and associated morbidity remain underdiagnosed, routine screening for unhealthy use is recommended by the U.S. Preventive Services Task Force as a cost-effective, clinical preventive service. Incorporating alcohol biomarker testing is recommended by the American Society of Addiction Medicine and the American Psychiatric Association to help diagnose AUD and support patient recovery.4

Blood alcohol biomarker testing

Our blood biomarker testing to evaluate for PEth provides an expanded window of detection to identify ethanol consumption. PEths, a group of phospholipids formed in the presence of ethanol, phospholipase D, and phosphatidylcholine, are incorporated into the phospholipid membrane of red blood cells. Based on blood concentrations of PEth, it is possible to determine recent alcohol consumption and how much has been taken for several weeks following the last use.

Key testing


Direct urine alcohol biomarker testing

Our urine alcohol testing offers clinical specificity to evaluate for alcohol use through the detection of EtG and EtS. These assays offer an extended window of detection that can reliably identify alcohol consumption in urine up to five days, which helps facilitate diagnosis and assists in monitoring ethanol abstinence or relapse in outpatients treated for alcohol-related problems.

Key testing

  1. U.S. Preventive Services Task Force. (2018). Final recommendation statement: Unhealthy alcohol use in adolescents and adults: Screening and behavioral counseling interventions. Retrieved from
  2. Chaudhari R, Moonka D, Nunes F. Using biomarkers to quantify problematic alcohol use. J Fam Pract. 2021 Dec;70(10):474-481. doi:10.12788/jfp.0317
  3. Key Substance Use and Mental Health Indicators in the United States: Results from the 2018 National Survey on Drug Use and Health (
  4. Jarvis M., Williams J., Hurford M., et al. Appropriate use of drug testing in clinical addiction medicine. J Addict Med. 2017 May/Jun;11(3):163-173. doi:10.1097/ADM.0000000000000323
  5. Centers for Disease Control and Prevention. Alcohol-Related Disease Impact (ARDI) website. Accessed April 19, 2022.
  6. Sacks JJ, Gonzales KR, Bouchery EE, Tomedi LE, Brewer RD. 2010 National and state costs of excessive alcohol consumption. Am J Prev Med. 2015;49(5):e73–e79
  7. Kapur B, Aleksa K., What the lab can and cannot do: clinical interpretation of drug testing results. Crit Rev Clin Lab Sci. 57:8, 548-585. doi:10.1080/10408363.2020.1774493
  8. Niemela, O. Biomarker-based approaches for assessing alcohol use disorders. Int J Environ Res Public Health. 2016 Jan 27;13(2):166. doi:10.3390/ijerph13020166
  9. Hakim F, Wiart JF, Ménard O, Allorge D, Gaulier JM. Dosage sanguin du phosphatidyléthanol [Phosphatidylethanol blood analysis]. Ann Biol Clin (Paris). 2019 Dec 1;77(6):638-644. French. doi:10.1684/abc.2019.1499. PMID: 31859640
  10. Ulwelling W, Smith K. The PEth blood test in the security environment: what it is; why it is important; and interpretative guidelines. J Forensic Sci. 2018 Nov;63(6):1634-1640. PMID: 30005144

Fill out the form below and one of our specialists will be in touch.