Like a thief in the night, multiple myeloma sneaks up on people. The incurable blood cancer almost always starts as a relatively benign condition—monoclonal gammopathy of undetermined significance, or MGUS—that has no symptoms and often goes undiagnosed.
After a long wait, the U.S. Food and Drug Administration has finally approved the Elecsys Troponin T Gen 5 STAT blood test. Recently, the Beckman hscTnI assay was also approved. These high-sensitivity troponin assays will benefit emergency departments across the country because the results will allow for earlier and faster recognition of acute myocardial infarction, which interrupts the blood supply to an area of the heart.
Now in its second year of a five-year initiative to better understand and detect arboviruses in Belize, the IMPACTS (Integrated Mayo Clinic Program for Arbovirus Community health education Training and Surveillance) project has expanded its focus to include tick-borne infections in addition to mosquito-borne diseases, like Zika and dengue. IMPACTS is a four-tiered project that is a joint effort with Mayo Clinic, the University of Notre Dame’s Eck Institute for Global Health, and the Belize Ministry of Health.
Gadolinium-based contrast agents (GBCAs) have revolutionized MRIs by increasing the clinical utility and detection sensitivity of these exams. GBCAs also contain gadolinium, a rare earth metal with unique chemical properties. This article discusses the recent discovery that small amounts of gadolinium remain in human brain tissue following intravenous administration of GBCAs.
For people with encephalitis, rapid treatment of their acute brain inflammation is critical for avoiding devastating physical and cognitive deficits. But appropriate treatment requires identifying the culprit causing the symptoms.
A breakthrough in pathology, achieved more than a century ago (allegedly on a frozen window ledge in Rochester, Minnesota) has evolved into an innovative aspect of care at Mayo Clinic. Mayo is one of the only medical centers in the United States to routinely use a tissue-freezing process that provides analysis of tissue samples while the patient is still in the operating room.
By taking into account an individual’s genes, lifestyle, and environment, precision medicine offers the prospect of finding individualized therapies that might ultimately cure diseases such as cancer and diabetes. Yet, as with other technological revolutions, precision medicine’s quest for innovation bumps up against a host of legal issues—for patients as well as laboratories and providers of care.
A recent Mayo Clinic study has found that many U.S. health care providers are habitually ordering a mostly unnecessary, and quite expensive, genetic test to identify a patient’s hereditary risk of venous thromboembolism.
A team of Mayo Clinic pathologists have discovered a new tissue biomarker, DNAJB9, for fibrillary glomerulonephritis, a rare kidney disease of unknown pathogenesis and poor outlook—nearly half of all patients end up on dialysis within four years of diagnosis.
Newborn screening panels (that test for a variety of conditions) are available in every state; however, test performance and response rate by each state is very different. Mayo Clinic’s Biochemical Genetics Laboratory created the Collaborative Laboratory Integrated Reports tool to mitigate the national (and international) problem of false positives and to raise the bar on test performance.
Teamwork is critical among staff from Mayo Clinic, the Centers for Disease Control and Prevention, Minnesota Department of Health, and the University of Wisconsin-Madison in order to keep tabs on tick trends and defend against vector-borne diseases.