Mayo Clinic Laboratories > Immunology

Clarity for challenging conditions

Immunology testing at Mayo Clinic Laboratories is supported by a multidisciplinary team of experts who apply the latest research to propel the development of meaningful assays. These tests are used to assist with disease identification, monitoring of disease processes, and monitoring and treatment of rare immunologic illnesses.

Through ongoing research and clinical trials, our experts are pushing the boundaries of knowledge for the most confounding immunologic syndromes, such as mast cell activation syndrome and eosinophilic disorders. Discoveries made through Mayo Clinic-led research are implemented into pioneering testing that helps improve patients’ lives.

Immunology test menu

Allergen testing Allergen testing
Allergen testing

We offer an array of specific IgE (sIgE) blood testing, commonly called radioallergosorbent test (RAST) or ImmunoCAP testing, to measure allergy-causing antibodies, known as immunoglobulin E (IgE) antibodies, in the blood.

Autoimmune neurological disorders Autoimmune neurological disorders
Autoimmune neurological disorders

Covering the spectrum of autoimmune neurological disorders, our evaluations apply a phenotype-specific approach to diagnose and guide treatment for patients affected by immune-mediated neurological illness.

Hereditary immunologic disorders Hereditary immunologic disorders
Hereditary immunologic disorders

Our robust offerings for inborn errors of immunity, which include testing for inherited cytopenia, immunodeficiencies, disorders of immune regulation, and viral susceptibility, among others, can assist with classifying the disorder, clarifying prognosis, and guiding treatment decisions.

Inflammatory bowel disease Inflammatory bowel disease
Inflammatory bowel disease

Our comprehensive inflammatory bowel disease (IBD) testing includes calprotectin testing to diagnose IBD or irritable bowel syndrome (IBS); serologic testing to diagnose ulcerative colitis and Crohn’s disease; thiopurine therapeutic monitoring; genetic testing for the identification of monogenic IBD; and biologics testing to measure immunogenicity and drug resistance.

Mast cell activation syndrome Mast cell activation syndrome
Mast cell activation syndrome

Our robust portfolio of urine mediator tests for mast cell activation syndrome provides noninvasive options to support diagnosis of this complex condition.

Rheumatic disease Rheumatic disease
Rheumatic disease

Our rheumatology test menu includes assays to diagnose and characterize disease and monitor treatment for rheumatic conditions.

Our difference

Driving innovation
Basic and translational immunology research at Mayo Clinic drives the discovery and understanding of immune system biology. By increasing knowledge of how the immune system works, we can advance the development of novel tests for people with allergies, chronic inflammation, and other immune-related diseases.

Patient-first approach
The unique collaboration between Mayo Clinic Laboratories and the clinical practice at Mayo Clinic enables the development of advanced, patient-focused testing that meets a medical need. When Mayo Clinic physicians, through patient care, identify a need for a new diagnostic test, our robust innovation hub develops a test for clinical use. 

Unparalleled expertise
Our multidisciplinary team of immunology experts, clinicians, and laboratory scientists delivers the highest standard of laboratory care for immunologic disease. In addition to possessing expertise in specific areas, our laboratory specialists are involved in interactive research that expands what is known about immune system disorders. Our laboratory physicians, scientists, and genetic counselors are able to discuss orders, results, or diagnostic next steps.

News and updates

The latest

Lupus: Novel Testing for Assessment and Treatment

The following cases are designed for healthcare professionals interested in understanding the assessment and treatment options for patients with systemic lupus erythematosus disease.

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Grounded in gratitude, embracing treatment with hope

The fifth episode of “Life of a Specimen” video series highlights Joy Carol’s treatment journey after Mayo Clinic Laboratories antibody testing identified a paraneoplastic autoimmune disorder as the cause of her life-threatening symptoms.

A decade-long search for answers ends at Mayo Clinic: Tyler Hart

After years of misdiagnosis, Tyler Hart found answers at Mayo Clinic, discovering he had NF155-IgG4 autoimmune nodopathy instead of CIDP

A clearer path through a difficult diagnosis

The fourth episode of “Life of a Specimen” video series explores the diagnosis enabled by antibody testing on Joy Carol’s cerebrospinal cord fluid and how her test result illuminated a path forward.

Integration, innovation, precision: Propelling leading-edge diagnostics

The third episode of “Life of a Specimen” video series discusses the integration that drives the development of innovative tests, including the movement disorders evaluation, at Mayo Clinic Laboratories.

The specimen’s journey to the laboratory: Refined processes, superior quality, unwavering care

Check out the second episode of “Life of a Specimen,” a video exploration of the complex path taken by patient samples through testing at Mayo Clinic Laboratories. In this episode, we hear about the quality processes and careful treatment given to each sample received for testing.

Saving and improving lives: The illuminating journey of a laboratory testing specimen

Check out the first episode of “Life of a Specimen,” a video series that examines the critical journey taken by patient samples through Mayo Clinic Laboratories testing. In this video, we learn about the profound impact of our testing on one extraordinary patient.

Six ways innovative lupus tests are transforming patient and clinician experiences

The Lupus Foundation of America estimates that at least five million people worldwide have a form of lupus. Yet, the most widely used laboratory tests for patients with this complex condition were developed more than 60 years ago, and physicians need modern, evidence-based tools to provide high-quality care for their patients. That is why Mayo Clinic Laboratories and Progentec Diagnostics joined forces to provide solutions that transform that experience.

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