Detecting a rare, autoimmune neuropathy    

Precision testing expediates DADS diagnosis

Distal acquired demyelinating symmetric neuropathy (DADS) is correlated to the presence of anti-myelin associated glycoprotein (MAG) antibodies. In anti-MAG neuropathy, or DADS, the body generates monoclonal immunoglobulin (IgM) antibodies that bind to and prevent MAG antibodies from properly signaling the nervous system, which causes motor and sensory issues.

Although most anti-MAG neuropathy cases have an associated IgM M-protein, traditional testing approaches (e.g., serum electrophoresis and immunofixation) can sometimes be negative, which delays diagnosis. The enhanced sensitivity and specificity of MASS-FIX enables detection of the lowest possible amount of M-proteins, providing diagnostic certainty for the rare, hard-to-treat illness.

Test menu

Screening and diagnosis

DMOGA  | Monoclonal Gammopathy, Diagnostic, Serum

Analytic time: 2 days  

Appropriate ordering scenario 

  • Assessing the risk of progression from MGUS to multiple myeloma 

PEISO  | Protein Electrophoresis and Isotype, Serum

Analytic time: 2 days  

Appropriate ordering scenario 

  • Diagnosis of monoclonal gammopathies, when used in conjunction with serum free light-chain studies performed at client site 

MALD  | M-Protein Isotype, Matrix-Assisted Laser Desorption-Ionization Time-of-Flight Mass Spectrometry, Serum

Analytic time: Same day/1 day 

Appropriate ordering scenario 

  • When protein electrophoresis and free light-chain testing is performed in-house; M-protein isotyping by MASS-FIX only 

Learn more about how to order these tests at your institution.