Precision testing expediates DADS diagnosis

Distal acquired demyelinating symmetric neuropathy (DADS) is correlated to the presence of anti-myelin associated glycoprotein (MAG) antibodies. In anti-MAG neuropathy, or DADS, the body generates monoclonal immunoglobulin (IgM) antibodies that bind to and prevent MAG antibodies from properly signaling the nervous system, which causes motor and sensory issues.

Although most anti-MAG neuropathy cases have an associated IgM M-protein, traditional testing approaches (e.g., serum electrophoresis and immunofixation) can sometimes be negative, which delays diagnosis. The enhanced sensitivity and specificity of MASS-FIX enables detection of the lowest possible amount of M-proteins, providing diagnostic certainty for the rare, hard-to-treat illness.

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