MASS-FIX detects M-protein related kidney disease
Renal disorders caused by monoclonal immunoglobin (IgM) lack the malignant implications of hematologic plasma cell disorders; however, they are associated with increased morbidity due to the severity of renal (sometimes systemic) lesions caused by IgM. Low occurrence of monoclonal gammopathy of renal significance (MGRS) has resulted in poorly defined best-practices for testing in patients with chronic kidney disease.
Utilizing highly sensitive, MALDI-TOF mass spectrometry to detect IgM, or M-proteins, facilitates diagnosis across a spectrum of IgM-associated renal disorders, including AL amyloidosis, proliferative glomerulonephritis with monoclonal Ig deposits, and C3 glomerulopathy. Early identification of MGRS is vital since targeted suppression of IgM secretion through chemotherapy frequently improves outcomes.
The new MASS-FIX testing method provides:
Screening and diagnosis
DMOGA | Monoclonal Gammopathy, Diagnostic, Serum
Analytic time: 2 days
Appropriate ordering scenario
PEISO | Protein Electrophoresis and Isotype, Serum
Analytic time: 2 days
Appropriate ordering scenario
Analytic time: Same day/1 day
Appropriate ordering scenario
Learn more about how to order these tests at your institution.
Relevant publications from Mayo Clinic