Page Banner
Mayo Clinic Laboratories > Neurology > Autoimmune

Autoimmune neurology

Patient Spotlight A Mayo Pathologist’s Journey through Paraneoplastic Syndrome and a Double Lung Transplant: Dr. Brad Karon
Patient Spotlight Rare patient case helps inform and validate GABA-A-R antibody encephalitis testing: JoAnne Michael
Answers From the Lab Tests Aid Diagnosis of Cancer-Associated Neurological Disorders
Answers From the Lab Updates Streamline Autoimmune Neurology Testing
Video Watch our neurology experts in action
Answers From the Lab Learn about our novel test for detecting Ma2 antibodies
Education Elevate understanding with a phenotypic approach

At the forefront of a testing evolution

Autoimmune neurology is a rapidly evolving subspecialty driven by the discovery that the immune system can target virtually any structure within the central and peripheral nervous systems. These conditions manifest as disorders previously thought to be independent and unrelated, and early and accurate diagnosis is paramount.

We are leading an evolution in autoimmune neurology diagnosis, with a phenotype-specific testing approach to effectively diagnose and guide treatment for these patients.

AUTOIMMUNE NEUROLOGY TEST MENU

Dementia Dementia
Dementia

Using an indirect immunofluorescence assay, our autoimmune dementia panel evaluates for the presence of nearly 20 antibodies associated with immune-mediated dementia.  

Encephalopathy Encephalopathy
Encephalopathy

Recently identified as being as common as infectious encephalitis, autoimmune encephalitis can have devastating results when misdiagnosed. Our testing features both robust panels and unique stand-alone evaluations to detect antibodies related to rare and complex cases of autoimmune encephalopathy. Developed by some of the world’s most knowledgeable autoimmune neurology specialists, our encephalopathy evaluations can pinpoint the correct cause and propel appropriate treatment.

Epilepsy Epilepsy
Epilepsy

Proper identification of immune-mediated epilepsy is vital to directing appropriate treatment. Our autoimmune epilepsy evaluation detects for more than a dozen antibody biomarkers related to autoimmune causes.

Movement disorders Movement disorders
Movement disorders

Our comprehensive autoimmune movement disorders panel is continuously updated to include newly discovered antibody biomarkers and uses advanced testing approaches to detect actionable antibodies. Data-backed and developed by our autoimmune neurology experts, our evaluations include detection of several antibody biomarkers available only at Mayo Clinic Laboratories.

Myasthenia gravis and Lambert-Eaton Myasthenia gravis and Lambert-Eaton
Myasthenia gravis and Lambert-Eaton

Our reflexive approach to testing for myasthenia gravis and Lambert-Eaton syndrome optimizes diagnosis to expedite treatment. Consisting of upfront and confirmatory antibody testing, followed by automatic second-line testing, our diagnostic algorithm enables faster, more accurate answers for more patients.

Myelopathy Myelopathy
Myelopathy

Mayo Clinic Laboratories is the only laboratory in the world to offer testing for a novel form of relapsing autoimmune meningoencephalomyelitis. Known as autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy, the antibody is one of more than a dozen included in our phenotypic-specific autoimmune myelopathy evaluation.

Necrotizing autoimmune myopathy Necrotizing autoimmune myopathy
Necrotizing autoimmune myopathy

Our necrotizing autoimmune myopathy evaluation detects for HMGCR-IgG and SRP-IgG, which are the two most pertinent antibodies associated with the devastating condition.

Neuropathies Neuropathies
Neuropathies

We offer a full menu of autoimmune neuropathy tests that evaluate for specific antibody biomarkers linked to the illness. Using electrophysiology test results as a determining factor for which test to order, our expert-backed evaluations provide accurate results to confirm diagnosis and set patients on the best treatment path.

Pediatric disorders Pediatric disorders
Pediatric disorders

Designed specifically for children, our unique profile includes only those antibodies pertinent to pediatric central nervous system disorders.

Vision loss Vision loss
Vision loss

Including antibodies known for their association with paraneoplastic retinopathy or cancer-associated retinopathy, our distinct autoimmune vision loss panel can help individuals with rapidly progressive vision loss when paraneoplastic causes, such as retinopathy or optic neuritis, are suspected.  

A history of innovation and discovery

The Mayo Clinic Neuroimmunology Laboratory was the first to introduce comprehensive serological evaluations for the diagnosis of paraneoplastic neurologic autoimmune disorders, a group of disorders in which unusual neurologic signs and symptoms are the initial manifestations of cancer.

The laboratory continues to discover and clinically validate novel autoantibody profiles that inform neurological decision-making and guide the search for cancer, leading an evolution in autoimmune neurology diagnosis. Powered by expertise from our research labs, clinical labs, and Autoimmune Neurology Clinic, we have developed panels customized to address specific phenotypes. This approach delivers more clinically actionable results, providing a clear picture of the diagnosis, prognosis, and treatment options.

“Clinicians are used to looking for patterns in their clinical work, and we’re transferring that expertise into a clinical laboratory space. That’s not something that you learn overnight — it’s gained with experience over years.”

Andrew McKeon, M.B., B.Ch., M.D.

News and updates

The latest

PDE10A autoimmunity presents as hyperkinetic movement disorder triggered by ICI treatment featured image
PDE10A autoimmunity presents as hyperkinetic movement disorder triggered by ICI treatment

Find out how our suite of autoimmune movement disorder testing can help diagnose PDE10A autoimmunity in patients who present with hyperkinetic movement disorders.

Learn more
Behind the scenes in neural antibody testing

In this month’s “Hot Topic,” John Mills, Ph.D., explains the central role of tissue immunofluorescence in the identification of neural antibodies and discusses the benefits of an integrated laboratory approach to the development and validation of novel antibody biomarkers.

Pediatric Autoimmune CNS Disorders Evaluation

The clinical presentations, evaluation (including diagnostic antibody testing), and treatment of autoimmune pediatric CNS disorders, including encephalitides and myelopathies.

Resources
Learn more Autoimmune neurology antibody matrix
Learn more Antibody prevalence in epilepsy and encephalopathy (APE2) score
Learn more Autoimmune neurology test ordering guide
(BETA) Choose a language to view this content in:
About the translation.