Pediatric central nervous system (CNS) tumors have higher instances of gene fusions than adults. And some pediatric tumor types, including medulloblastoma, have molecular characteristics affiliated with distinct clinical outcomes.1 Precision analysis that simultaneously detects for multiple biomarkers can provide a heightened understanding of the genetic landscape of a child’s tumor.
26% of pediatric cancers are central nervous system2
48% of pediatric cancer patients who underwent molecular testing were identified as having an actionable mutation3
Our pediatric-focused molecular testing provides robust coverage of established and emerging cancer-related gene expression, including mutations, rearrangements, fusions, and copy number variants. Developed in collaboration with Mayo Clinic neuro-oncologists, molecular geneticists, and genetic counselors, our testing covers an array of CNS cancers, including medulloblastoma, pilocytic astrocytoma, pediatric-type gliomas, and neuroblastoma.
Molecular biomarkers are a critical component in the treatment of adult and pediatric brain tumors. Robert Jenkins, M.D., Ph.D., explains how Mayo Clinic Laboratories' chromosomal microarray provides more comprehensive and accurate tumor analysis compared with other test methods.
Cristiane (Cris) Ida, M.D., explains how Mayo Clinic Laboratories' updated neuro-oncology gene panel provides more clinically relevant information for managing adult and pediatric brain tumors.
Menyhárt O, Győrffy B. Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches. Cancer Metastasis Rev. 2020;39(1):211-233. doi:10.1007/s10555-020-09854-1.
Lee J, Gillam L, Visvanathan K, Hansford J, McCarthy M. Clinical utility of precision medicine in pediatric oncology: a systemic review. JCO Precision Oncology. 2021 :5, 1088-1102
Goldman R, Chang S, Cochrane D. Improving diagnosis of pediatric central nervous system tumors: aiming for early detection. CMAJ. March 27, 2017 189 (12) E459-E463; doi:https://doi.org/10.1503/cmaj.160074.
INTERESTED IN LEARNING MORE?
Fill out the form below and one of our specialists will be in touch.