Hot Topic

Hot Topic

In this month’s “Hot Topic,” Dragan Jevremovic, M.D., Ph.D., reviews the diagnostic criteria for multiple myeloma and discusses the laboratory tests, including the use of next-generation sequencing, that can be used to help diagnose and manage patients with this disease.

By MCL Education • June 5, 2017

In this “Hot Topic,” Daniel Visscher, M.D., discusses the Mayo Clinic experience in identifying biopsy specimens that demonstrate mucocele-like lesions of the breast and the associated risk of breast cancer.

By MCL Education • May 22, 2017

Millions of Americans suffer from allergies with peanut allergies being of particular interest. In this “Hot Topic,” Melissa Snyder, Ph.D., discusses the diagnosis of allergic disease and the role of component allergen testing.

By MCL Education • April 17, 2017

In this “Hot Topic,” Roshini Abraham, Ph.D., will the discuss the complexity of diagnosing chronic granulomatous disease (CGD) and the DHR/Dihydrorhodamine (DHR) Flow Cytometric Test, blood assay as the most commonly used assay for diagnosis.

By MCL Education • March 20, 2017

Clostridium difficile is an important cause of health care-associated infections. C. difficile infections (CDI) present with a wide range of symptoms, from diarrhea to toxic megacolon. In this “Hot Topic,” Audrey Schuetz, M.D., covers several methods for diagnosing CDI, including molecular NAATs, EIAs, and culture.

By MCL Education • March 6, 2017

In this “Hot Topic,” Darci Block, Ph.D., will explain how a team from Mayo Clinic evaluated collecting blood from infants using the practice of warming the heel prior to puncture, using venipuncture instead of heel puncture, and infant distress as a result of either heel puncture or venipuncture.

By MCL Education • February 20, 2017

Programmed cell death ligand 1 (PD-L1) is a protein that can be expressed on tumor cells and immune cells. In this “Hot Topic,” Anja Roden, M.D., discusses the role of PD-1 – PD-L1 interaction in the immune system and the challenges of PD-L1 testing.

By MCL Education • February 7, 2017

Knowing which test is the correct test can be difficult. Ordering the wrong test can provide misleading results and increase costs to the patient. In this “Hot Topic,” Sarah Kerr, M.D., explains similarities and differences between mismatched repair defects and microsatellite instability when screening patients for Lynch syndrome.

By MCL Education • January 16, 2017

Because many patients with lung cancer are not surgical candidates, the biopsy specimen or cytology preparation will be the only specimen available for diagnosis and molecular testing in these patients. In this “Hot Topic,” Anja Roden, M.D., covers a new classification of small biopsies and cytology in the 2015 WHO classification of lung adenocarcinoma.

By MCL Education • January 3, 2017

In this “Hot Topic,” Nancy Wengenack, Ph.D., provides an overview of the current standards for antifungal drug-susceptibility testing of yeast and the development of species-specific breakpoints and epidemiological cutoff values.

By MCL Education • December 19, 2016

Fibrolamellar carcinoma is a rare subtype of primary liver cancer, and the diagnosis can sometimes be difficult. In this “Hot Topic” we discuss a new test, developed at Mayo Clinic, that uses FISH technology to identify the fusion gene DNAJB1-PRKACA, reported in fibrolamellar carcinomas.

By MCL Education • December 5, 2016

Influenza testing has changed significantly in the last 10 years. View our latest “Hot Topic” to understand the different testing methods and the environments in which they are most appropriate.

By MCL Education • November 22, 2016

This “Hot Topic” discusses the amount of tumor tissue in a specimen and the percent tumor nuclei as the foundation for selecting the right specimen for molecular testing. Once you’ve correctly identified the target, the requirements for the specific type of test come into play.

By MCL Education • November 7, 2016