Hot Topic

Hot Topic

In this “Hot Topic,” Nicole Hoppman, Ph.D., discusses mate-pair sequencing, which is the first clinically available test that can characterize almost any chromosomal rearrangement, helping to establish pathogenicity, and, in a neoplastic setting, assist in diagnosis, prognosis, and identification of optimal therapeutic options.

By Nicole Hoppman, Ph.D. • September 5, 2017

In this month’s “Hot Topic,” Alicia Algeciras-Schimnich, Ph.D., will provide you with valuable information regarding the utility of the prostate specific antigen test, and how the calculation of a prostate health index, or phi, can help to stratify a patient’s risk for prostate cancer and reduce unnecessary biopsies.

By Alicia Algeciras-Schimnich, Ph.D. • August 14, 2017

In this month’s “Hot Topic,” Ariela Marshall, M.D., provides an overview of venous thromboembolism in the pregnant population, including its risk factors, treatment, and prevention.

By Ariela Marshall, M.D. • July 17, 2017

Diabetes mellitus type 1 accounts for most juvenile-onset diabetes. In this “Hot Topic,” Andrew McKeon, M.D., discusses a new diabetes evaluation that is now available to help detect disease, differentiate between diabetes type 1 and type 2, and aid in the risk assessment for future diabetes risk.

By MCL Education • July 3, 2017

In this month’s “Hot Topic,” Dragan Jevremovic, M.D., Ph.D., reviews the diagnostic criteria for multiple myeloma and discusses the laboratory tests, including the use of next-generation sequencing, that can be used to help diagnose and manage patients with this disease.

By MCL Education • June 5, 2017

In this “Hot Topic,” Daniel Visscher, M.D., discusses the Mayo Clinic experience in identifying biopsy specimens that demonstrate mucocele-like lesions of the breast and the associated risk of breast cancer.

By MCL Education • May 22, 2017

Millions of Americans suffer from allergies with peanut allergies being of particular interest. In this “Hot Topic,” Melissa Snyder, Ph.D., discusses the diagnosis of allergic disease and the role of component allergen testing.

By MCL Education • April 17, 2017

In this “Hot Topic,” Roshini Abraham, Ph.D., will the discuss the complexity of diagnosing chronic granulomatous disease (CGD) and the DHR/Dihydrorhodamine (DHR) Flow Cytometric Test, blood assay as the most commonly used assay for diagnosis.

By MCL Education • March 20, 2017

Clostridium difficile is an important cause of health care-associated infections. C. difficile infections (CDI) present with a wide range of symptoms, from diarrhea to toxic megacolon. In this “Hot Topic,” Audrey Schuetz, M.D., covers several methods for diagnosing CDI, including molecular NAATs, EIAs, and culture.

By MCL Education • March 6, 2017

In this “Hot Topic,” Darci Block, Ph.D., will explain how a team from Mayo Clinic evaluated collecting blood from infants using the practice of warming the heel prior to puncture, using venipuncture instead of heel puncture, and infant distress as a result of either heel puncture or venipuncture.

By MCL Education • February 20, 2017

Programmed cell death ligand 1 (PD-L1) is a protein that can be expressed on tumor cells and immune cells. In this “Hot Topic,” Anja Roden, M.D., discusses the role of PD-1 – PD-L1 interaction in the immune system and the challenges of PD-L1 testing.

By MCL Education • February 7, 2017

Knowing which test is the correct test can be difficult. Ordering the wrong test can provide misleading results and increase costs to the patient. In this “Hot Topic,” Sarah Kerr, M.D., explains similarities and differences between mismatched repair defects and microsatellite instability when screening patients for Lynch syndrome.

By MCL Education • January 16, 2017

Because many patients with lung cancer are not surgical candidates, the biopsy specimen or cytology preparation will be the only specimen available for diagnosis and molecular testing in these patients. In this “Hot Topic,” Anja Roden, M.D., covers a new classification of small biopsies and cytology in the 2015 WHO classification of lung adenocarcinoma.

By MCL Education • January 3, 2017