This “Hot Topic” discusses the amount of tumor tissue in a specimen and the percent tumor nuclei as the foundation for selecting the right specimen for molecular testing. Once you’ve correctly identified the target, the requirements for the specific type of test come into play.
In this “Hot Topic,” William Nichols, M.D., presents a case study that demonstrates how pre- and postanalytic variables of the patient and blood samples can have confounding effects on the laboratory evaluation of coagulation disorders.
In this “Hot Topic,” Sean Pittock, M.D., introduces a new FACS Assay for detection of Aquaporin4-IgG discovered in the lab, which is required for the diagnosis of neuromyelitis optica spectrum disorders and allows for distinction from multiple sclerosis.
In this “Hot Topic,” Paul Jannetto, Ph.D., talks about a new high-resolution targeted opioid screening test from Mayo Medical Laboratories offering improved sensitivity and specificity for use in the monitoring and management of patients who are prescribed opioid pain relieving medication.
The differential diagnosis for inflammatory bowel disease (IBD) includes irritable bowel syndrome (IBS). While the clinical presentation is similar, IBD is an inflammatory disease, while IBS is a noninflammatory disease. View this “Hot Topic” to learn about testing for IBD and IBS.
In this “Hot Topic,” Theresa Kinard, M.D., provides an overview of heparin anticoagulation monitoring and the use of the activated partial thromboplastin time and the chromogenic anti-Xa assay.
Membranoproliferative glomerulonephritis (MPGN) is a pattern of glomerular injury. Based on the etiology of MPGN, Drs. Sethi and Fervenza proposed a new histologic classification of MPGN into Ig/IC-mediated MPGN and complement-mediated MPGN. In this “Hot Topic,” Dr. Senjeev Sethi, M.D., Ph.D., demonstrates the use of the new classification with case studies.
Membranoproliferative glomerulonephritis (MPGN) is a pattern of glomerular injury. Based on the etiology of MPGN, Drs. Sethi and Fervenza proposed a new histologic classification of MPGN into Ig/IC-mediated MPGN and complement-mediated MPGN. In this “Hot Topic,” Senjeev Sethi, M.D., Ph.D., demonstrates the use of the new classification with case studies.
In part 1 of this 2-part “Hot Topic” presentation, Matt Binnicker, Ph.D., focused on cytomegalovirus infection. In part 2, he presents a case study of an Epstein-Barr virus (EBV) infection in a transplant patient.
In this “Hot Topic,” Bobbi Pritt, M.D., discusses how Lyme disease is the most common vector-borne illness in the United States and Europe and caused primarily by Borrelia burgdorferi in the United States, while B burgdorferi, B afzelii, and B garinii cause Lyme disease in Europe. We will also discuss using PCR and melting curve analysis to identify a new species of Borrelia.
In this “Hot Topic,” Elitza Theel, Ph.D., discusses how common cases of presumed Lyme disease go unreported each year and discusses scenarios in which testing for Lyme disease is indicated and reviews both recommended and inappropriate testing methodologies. The overall focus is on performance of the CDC endorsed two-tiered serologic testing algorithm and the latest CDC recommendations.
Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) are viral pathogens that may cause significant morbidity and mortality following transplantation. In part 1 of this “Hot Topic,” Matt Binnicker, Ph.D., discusses the available test options, their strengths and weaknesses, and review a case study of Cytomegalovirus (CMV) infection.