Hot Topic

Hot Topic

In this “Hot Topic,” Darci Block, Ph.D., will explain how a team from Mayo Clinic evaluated collecting blood from infants using the practice of warming the heel prior to puncture, using venipuncture instead of heel puncture, and infant distress as a result of either heel puncture or venipuncture.

By MCL Education • February 20, 2017

Programmed cell death ligand 1 (PD-L1) is a protein that can be expressed on tumor cells and immune cells. In this “Hot Topic,” Anja Roden, M.D., discusses the role of PD-1 – PD-L1 interaction in the immune system and the challenges of PD-L1 testing.

By MCL Education • February 7, 2017

Knowing which test is the correct test can be difficult. Ordering the wrong test can provide misleading results and increase costs to the patient. In this “Hot Topic,” Sarah Kerr, M.D., explains similarities and differences between mismatched repair defects and microsatellite instability when screening patients for Lynch syndrome.

By MCL Education • January 16, 2017

Because many patients with lung cancer are not surgical candidates, the biopsy specimen or cytology preparation will be the only specimen available for diagnosis and molecular testing in these patients. In this “Hot Topic,” Anja Roden, M.D., covers a new classification of small biopsies and cytology in the 2015 WHO classification of lung adenocarcinoma.

By MCL Education • January 3, 2017

In this “Hot Topic,” Nancy Wengenack, Ph.D., provides an overview of the current standards for antifungal drug-susceptibility testing of yeast and the development of species-specific breakpoints and epidemiological cutoff values.

By MCL Education • December 19, 2016

Fibrolamellar carcinoma is a rare subtype of primary liver cancer, and the diagnosis can sometimes be difficult. In this “Hot Topic” we discuss a new test, developed at Mayo Clinic, that uses FISH technology to identify the fusion gene DNAJB1-PRKACA, reported in fibrolamellar carcinomas.

By MCL Education • December 5, 2016

Influenza testing has changed significantly in the last 10 years. View our latest “Hot Topic” to understand the different testing methods and the environments in which they are most appropriate.

By MCL Education • November 22, 2016

This “Hot Topic” discusses the amount of tumor tissue in a specimen and the percent tumor nuclei as the foundation for selecting the right specimen for molecular testing. Once you’ve correctly identified the target, the requirements for the specific type of test come into play.

By MCL Education • November 7, 2016

In this “Hot Topic,” William Nichols, M.D., presents a case study that demonstrates how pre- and postanalytic variables of the patient and blood samples can have confounding effects on the laboratory evaluation of coagulation disorders.

By MCL Education • October 17, 2016

In this “Hot Topic,” Sean Pittock, M.D., introduces a new FACS Assay for detection of Aquaporin4-IgG discovered in the lab, which is required for the diagnosis of neuromyelitis optica spectrum disorders and allows for distinction from multiple sclerosis.

By MCL Education • October 3, 2016

In this “Hot Topic,” Paul Jannetto, Ph.D., talks about a new high-resolution targeted opioid screening test from Mayo Medical Laboratories offering improved sensitivity and specificity for use in the monitoring and management of patients who are prescribed opioid pain relieving medication.

By MCL Education • September 19, 2016

The differential diagnosis for inflammatory bowel disease (IBD) includes irritable bowel syndrome (IBS). While the clinical presentation is similar, IBD is an inflammatory disease, while IBS is a noninflammatory disease. View this “Hot Topic” to learn about testing for IBD and IBS.

By MCL Education • September 6, 2016

In this “Hot Topic,” Justin Kreuter, M.D., discusses platelet antibody testing.

By MCL Education • August 15, 2016