Individualized insights to guide personalized care 

Consolidated, full-spectrum genetic testing

For individuals with a personal or family history of cancer, germline testing can identify inherited causes of cancer as well as provide a detailed understanding of an individual’s risk of developing certain cancers, enabling tailored management for optimized outcomes. Germline testing may also provide insight on treatment approaches for some patients with cancer. Additionally, identifying pathogenic variants can support familial screening and genetic counseling for a variety of hereditary cancer syndromes.

By the numbers

1 in 8

cancer patients have a germline variant2


hereditary cancer syndromes have been described1


of patients identified to have germline variants benefit from tailored cancer treatment2

Expert-backed testing for hereditary cancers

Our hereditary cancer panels, developed by Mayo Clinic oncologists and backed by genetic counselors, utilize next generation sequencing (NGS) to evaluate dozens of genes associated with cancer risk. Test results, analyzed by Mayo Clinic experts, enable precision insights for individuals identified with hereditary cancer syndromes and those who are not. Our comprehensive, germline cancer analyses complement Mayo Clinic Laboratories’ somatic cancer testing, allowing for streamlined cancer evaluations in one laboratory.

Identifying inherited risk for family members 

Individuals without cancer can still have a hereditary cancer syndrome. If they have family members with cancer, genetic testing can clarify their own risks and management options. Our hereditary cancer panels provide family members with a deeper understanding of their risk for developing certain types of cancer, which can be helpful to plan for the future. 

Hereditary oncology: Molecular testing for solid tumors

In this episode of “Lab Medicine Rounds,” Sounak Gupta, M.B.B.S., Ph.D., assistant professor of Laboratory Medicine and Pathology at Mayo Clinic, discusses hereditary oncology and the importance of performing molecular testing of solid tumors.

Learn more about how to order these tests at your institution.


  1. The Genetics of Cancer. National Cancer Institute
  2. Samadder NJ, et. al. Comparison of Universal Genetic Testing vs Guideline-Directed Targeted Testing for Patients With Hereditary Cancer Syndrome. JAMA Oncol. 2021 Feb 1;7(2):230-237. doi: 10.1001/jamaoncol.2020.6252. Erratum in: JAMA Oncol. 2021 Feb 1;7(2):312. PMID: 33126242; PMCID: PMC7600058.