TherapeuticS
Creating the new standard of therapeutic management, together
Mayo Clinic Laboratories’ evidence-based toxicology and pharmacogenomic testing utilizes innovative testing strategies and technologies to gain precision insights that help physicians guide patient care.
Developed by board-certified experts in clinical chemistry, molecular, and toxicology testing, our comprehensive therapeutics test offerings were designed to detect and monitor therapeutic and illicit drugs across several relevant specimen types.
Our robust test menu includes assays that span the range of drug testing specialties, providing accurate answers and personalized results to optimize the therapeutic management of complex and chronic conditions.
Highlights
Reviewing the challenges healthcare providers face in distinguishing between new and residual marijuana use in patients.
Register now: Aug. 13, 2025 - PACE/State of FL - The critical role of pharmacogenomics and therapeutic drug monitoring (TDM) in managing immunosuppressive therapy for solid organ transplant recipients.
Jessica Wright, Pharm.D., BCACP, explains how Mayo Clinic Laboratories' 3A5Q test helps determine initial tacrolimus doses for individuals after non-liver organ transplants. Optimal tacrolimus levels are one of the important factors in survival of the transplanted organ.
Kelly DuBois recently joined “Symptomatic: A Medical Mystery Podcast” to explain her health journey with Mayo Clinic. In the episode, Kelly, who faced a series of unexplained health issues over two decades, highlighted the help that Mayo Clinic was able to offer her after being misdiagnosed with acromegaly.
John Logan Black, M.D., explains how Mayo Clinic Laboratories' UGT1A1 tests (Mayo IDs: U1A1Q and UGTFZ) identify genetic variants that increase the risk of potentially life-threatening reactions to irinotecan, a chemotherapy agent.
PACE/State of FL - Substance use disorders and the common laboratory tests and matrices used for controlled substance monitoring.
Ann Moyer, M.D., Ph.D., explains how Mayo Clinic Laboratories' unique genetic tests identify patients at high risk of severe reactions to fluoropyrimidines — a type of chemotherapy drug. Test results can guide clinical decision-making for safer cancer treatment.
In a landmark discovery published in Clinical Chemistry, authenticated locks of hair from the composer Ludwig van Beethoven have revealed high lead concentrations after being analyzed at Mayo Clinic. Paul Jannetto, Ph.D., director of the Metals Laboratory at Mayo Clinic, along with his laboratory staff, completed testing on two independent and authenticated locks of Beethoven’s hair which confirmed the presence of high lead concentrations and could explain the cause for many of Beethoven’s ailments.
Paul Jannetto, Ph.D., explains the advantages that Mayo Clinic Laboratories' oral fluid drug screening offers over typical urine tests. Oral samples are easier to collect and harder to adulterate.
Tobacco use is the leading cause of preventable death in the United States. In this test-specific episode of the "Answers From the Lab" podcast, Paul Jannetto, Ph.D., explains how Mayo Clinic Laboratories' nicotine testing benefits patients in smoking cessation programs and other settings.
Recognizing the powerful role genes can play in diagnosing illness and guiding treatment, the Division of Laboratory Genetics and Genomics at Mayo Clinic spearheaded a testing expansion, implementing and upgrading more than 60 advanced sequencing and biochemical assays in 2023 and planning for even more this year.
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by Paul Jannetto, Ph.D., director of the Clinical and Forensic Toxicology Lab, Clinical Mass Spectrometry Lab, and Metals Lab at Mayo Clinic. Dr. Pritt and Dr. Jannetto discuss the current state of the opioid crisis in the United States, its impact on public health, and the important role of laboratory testing in addiction medicine and pain management patients.