Expert-backed, evidence-based testing
Definitive answers for toxicology testing
The Clinical and Forensic Toxicology Laboratory, Clinical Mass Spectrometry Laboratory, and Clinical Mass Spectrometry Development Laboratory at Mayo Clinic develop, implement, and perform clinical, forensic, and emergency toxicology testing on urine, serum, and meconium specimens received from Mayo Clinic, our regional practice, and clients around the world.
Backed by more than 45 years of clinical patient experience and expertise, our evaluations align with evidence-based clinical laboratory guidelines and use advanced and emerging technologies, including liquid chromatography tandem mass spectrometry (LC/MS/MS) and gas chromatography mass spectrometry (GS/MS), to deliver accurate, actionable results that clarify substance use for improved outcomes. Our highly trained, board-certified toxicology experts are available to discuss unexpected or unexplained results, provide ordering guidance, and offer testing education free of charge to our clients.
Our expanding menu of clinical toxicology testing includes comprehensive controlled substance monitoring and addiction rehabilitation monitoring. Using high-resolution accurate mass spectrometry in our evaluations enables precise identification of the parent drug and metabolites of commonly prescribed and abused controlled substances. Because effective monitoring of controlled substances begins with a valid specimen, our urine drug testing profiles start with specimen validity testing.
Our menu of emergency toxicology testing includes evaluations intended to manage an apparent overdose or intoxicated patients, or to determine if a specific set of symptoms might be due to the presence of drugs. Aimed at detecting drugs that have toxic effects but lack a known antidote or therapy, these evaluations are not appropriate for detecting drugs of abuse or screening for intermittent or illicit drug use.
In medicolegal circumstances where a patient’s drug testing results are presented as an exhibit of evidence in forensic or legal proceedings, maintaining the chain of custody is useful. Our chain of custody, or forensic toxicology, testing is performed under controlled conditions at our CLIA-certified Clinical and Forensic Toxicology Laboratory. We offer chain of custody process documentation for many of our drug tests.