Mayo Clinic Laboratories > Therapeutics > Clinical and forensic toxicology

Clinical and forensic toxicology

Definitive answers for toxicology testing

The Clinical and Forensic Toxicology Laboratory, Clinical Mass Spectrometry Laboratory, and Clinical Mass Spectrometry Development Laboratory at Mayo Clinic develop, implement, and perform clinical, forensic, and emergency toxicology testing on urine, serum, and meconium specimens received from Mayo Clinic, our regional practice, and clients around the world.

Backed by more than 45 years of clinical patient experience and expertise, our evaluations align with evidence-based clinical laboratory guidelines and use advanced and emerging technologies, including liquid chromatography tandem mass spectrometry (LC/MS/MS) and gas chromatography mass spectrometry (GS/MS), to deliver accurate, actionable results that clarify substance use for improved outcomes. Our highly trained, board-certified toxicology experts are available to discuss unexpected or unexplained results, provide ordering guidance, and offer testing education free of charge to our clients.

24/7

24/7 client support

45+

45+ years of clinical experience in toxicology testing

Testing services

Chain of custody testing Chain of custody testing
Chain of custody testing

Chain of custody drug testing is performed under controlled conditions at our CLIA-certified Clinical and Forensic Toxicology Laboratory in Rochester, Minnesota. Chain of custody process documentation is offered for many of our clinical drug tests. All chain of custody urine samples submitted receive adulterant testing and confirmation of all presumptive positive screening results.

Emergency toxicology Emergency toxicology
Emergency toxicology

Emergency drug testing at Mayo Clinic is performed 24 hours a day, seven days a week in the Clinical and Forensic Toxicology Laboratory. Designed to manage apparent overdose or intoxicated patients, our emergency and overdose testing can help determine whether symptoms are due to the presence of drugs.

Result interpretations Result interpretations
Result interpretations

Results from our assays are accompanied by interpretive reports that clearly identify the presence of prescribed, nonprescription, and illicit drugs. By including testing limitations, details on the window of drug detection, and information on the presence of pharmaceutical impurities and metabolic breakdowns of parent drugs, these enhanced reports provide important insights to guide treatment decisions.

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