Addiction rehabilitation monitoring     

Urine drug testing to monitor and support patient recovery

As part of an evidence-based addiction treatment program, comprehensive urine drug testing (UDT) can serve as a therapeutic tool in the assessment and management of patients across all phases of recovery from substance use disorders.1 Using objective measures, such as laboratory testing, to assess recent drug use and establish clinical goals enables successful patient rehabilitation and recovery.

Mayo Clinic Laboratories’ unique approach to UDT is consistent with American Society of Addiction Medicine’s national consensus statement3 recommending UDT to identify the presence of prescribed and approved medication taken as part of addiction recovery therapy, as well as illicit substances most commonly abused. Understanding which substances patients have ingested improves providers’ abilities to determine the effectivity of the treatment plan and provide motivation or reinforcement for abstinence.

By the numbers

40.3 Million

Americans age 12 or older were affected by a substance use disorder in 20202


reduction in substance misuse when clinical UDT is combined with other risk-mitigation strategies3


open Mayo Clinic clinical trials in psychiatry and psychology

Increase confidence through precision analysis

The Clinical and Forensic Toxicology Laboratory offers high-resolution, accurate mass spectrometry-based profiles to identify parent drugs and metabolites, including prescription drugs and illicit substances. Utilization of emerging technologies in our assays enables increased specificity to detect the lowest levels of substances, which correlates to a reduction in false positives. This decreases the need for unnecessary confirmatory testing often required with traditional immunoassay screens.

Key testing

ADMPU  | Addiction Medicine Profile with Reflex, 22 Drug Classes, High Resolution Mass Spectrometry and Immunoassay Screen, Random, Urine

Clinical utility

  • Detects recent drug use involving alcohol, amphetamine-type stimulants, barbiturates, benzodiazepines, cocaine, opioids, nicotine, and THC-COOH in urine.
  • Useful for the assessment and management of patients at risk for substance use disorders.


  • Identifies polysubstance use disorder and/or abuse to reduce adverse drug reactions (e.g., overdose toxicity).
  • Distinguishes active from passive tobacco use.
  • No charge for specimens identified as invalid due to adulteration (profile component Mayo ID: ADULT).
  • Enhanced sensitivity and specificity reduce the need for additional confirmatory testing required with traditional testing strategies.
  • Facilitates the appropriate use of testing methodologies to minimize costs and improve patient outcomes.

In instances where nicotine testing is not required, our enhanced controlled substance monitoring profile can provide accurate answers about other substance use.

A Test in Focus

Loralie Langman, Ph.D., and Paul Jannetto, Ph.D., co-directors of the Clinical and Forensic Toxicology Laboratory, discuss Mayo Clinic Laboratories’ approach to urine drug testing in the addiction rehabilitation space. The inclusion of alcohol and nicotine biomarker testing in our unique Addiction Rehabilitation Profile offers a comprehensive view of patients’ substance use to guide and monitor treatment and recovery.

Additional expert-backed testing available from Mayo Clinic Laboratories

The Clinical and Forensic Toxicology Laboratory at Mayo Clinic Laboratories offers the industry’s most comprehensive evidence-based urine drug testing profiles for Controlled Substance Monitoring to help physicians manage, monitor, and treat patients affected by substance use disorders. Because we understand that testing needs vary by institution and patient, we offer a menu of individually orderable, targeted, high-resolution evaluations for enhanced detection of specific drug classes.

In addition, we offer a full menu of confirmatory tests to substantiate results. These assays give providers the flexibility to perform immunoassays locally while enabling increased confidence through definitive testing. Check out our test requisition form for a full list of available testing.

Lab testing, simplified

Analysis of urine drug testing results by our experts, who apply the most up-to-date scientific data, enables clear answers that illuminate patients’ drug use. The inclusion of enhanced reports with interpretive comments simplifies results and enables transparency to support treatment. Learn more about Mayo Clinic Laboratories’ approach to interpreting urine drug test results.

The enhanced reports with interpretive comments included with test results contextualize findings by including details on the drug(s) prescribed, specimen type, and results of specimen validity testing. Unexpected or unexplained results should be discussed with the patient and laboratory, with additional testing performed as needed.

View a sample report.

Advancing the field of addiction medicine

The Clinical Forensic and Toxicology Laboratory works collaboratively with the Clinical Mass Spectrometry Laboratory to develop and validate drug testing in partnership with Mayo Clinic’s addiction specialists. Our clinically driven evaluations are backed by more than 45 years of clinical patient experience and expertise and deliver accurate, actionable results that clarify substance use for improved outcomes. Our experts are available to discuss unexpected or unexplained results, provide ordering guidance, and offer testing education free of charge to our clients.

Mayo Clinic is engaged in ongoing research on drug addiction and substance use disorders and offers several clinical trials to advance understanding of the condition. Check out our Clinical Trials page to learn more.

Learn more about how to order these tests at your institution.

Learn more about Mayo Clinic’s Addiction Services programs and addiction research.


  1. American Society of Addiction Medicine Consensus Statement on the Appropriate use of Drug Testing in Clinical Addiction Medicine. Thomson (
  2. American Society of Addiction Medicine National Practice Guideline For the Use of Medications in the treatment of Addiction Involving Opioid Use. The ASAM National Practice Guideline Supplement.pdf.
  3. National Center for Drug Abuse Statistics:
  4. U.S. Centers for Disease Control and Prevention – Excessive Alcohol Use:
  5. Substance Abuse and Mental Health Services Administration Highlights for the 2020 National Drug Survey on Drug Use and Health. 2020_NSDUH_Highlights.pdf (