Mayo Clinic Laboratories > Therapeutics > Clinical and forensic toxicology

Clinical and forensic toxicology

Definitive answers for toxicology testing

The Clinical and Forensic Toxicology Laboratory, Clinical Mass Spectrometry Laboratory, and Clinical Mass Spectrometry Development Laboratory at Mayo Clinic develop, implement, and perform clinical, forensic, and emergency toxicology testing on urine, serum, and meconium specimens received from Mayo Clinic, our regional practice, and clients around the world.

Backed by more than 45 years of clinical patient experience and expertise, our evaluations align with evidence-based clinical laboratory guidelines and use advanced and emerging technologies, including liquid chromatography tandem mass spectrometry (LC/MS/MS) and gas chromatography mass spectrometry (GS/MS), to deliver accurate, actionable results that clarify substance use for improved outcomes. Our highly trained, board-certified toxicology experts are available to discuss unexpected or unexplained results, provide ordering guidance, and offer testing education free of charge to our clients.

24/7

24/7 client support

45+

45+ years of clinical experience in toxicology testing

Testing services

Addiction rehabilitation monitoring Addiction rehabilitation monitoring
Addiction rehabilitation monitoring

Our approach to comprehensive drug testing for individuals in need of addiction rehabilitation testing aligns with the American Society of Addiction Medicine’s national consensus statement recommending drug testing to identify the presence of prescribed and approved medication taken as part of addiction recovery therapy, as well as illicit substances most commonly abused.

Chain of custody testing Chain of custody testing
Chain of custody testing

Chain of custody drug testing is performed under controlled conditions at our CLIA-certified Clinical and Forensic Toxicology Laboratory in Rochester, Minnesota. Chain of custody process documentation is offered for many of our clinical drug tests. All chain of custody samples submitted receive adulterant testing and confirmation of all presumptive positive screening results.

Confirmatory testing Confirmatory testing
Confirmatory testing

Our dual approach to definitive testing gives providers the flexibility to perform immunoassay screening locally while enabling confidence through confirmatory testing.

Controlled substance monitoring Controlled substance monitoring
Controlled substance monitoring

We offer the industry’s most comprehensive, evidence-based drug testing menu, which was developed with consistency to practice guidelines to help clinicians identify specific prescription drugs, adulterants, and illicit substances.

Emergency toxicology Emergency toxicology
Emergency toxicology

Emergency drug testing at Mayo Clinic is performed 24 hours a day, seven days a week in the Clinical and Forensic Toxicology Laboratory. Designed to manage apparent overdose or intoxicated patients, our emergency and overdose testing can help determine whether symptoms are due to the presence of drugs.

Result interpretations Result interpretations
Result interpretations

Analysis of drug testing results by our experts, who apply the most up-to-date scientific data, enables further transparency and clear answers that illuminate patients’ drug use. Learn more about interferences and impurities that might impact controlled substance simple screening results.

Therapeutic drug monitoring Therapeutic drug monitoring
Therapeutic drug monitoring

Our comprehensive therapeutic drug monitoring (TDM) test menu covers more than 70 drugs across psychiatry, neurology, transplant medicine, oncology, and other clinical disciplines, ensuring accurate, personalized care through advanced analysis and innovation.

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