Stories

In August of 2021, 28-year-old Mike Knudson, a Twin Cities resident known for his vibrant and active lifestyle, set out on what he anticipated to be an adventurous hiking vacation to the picturesque Glacier National Park in Montana. Little did he know that this journey in nature would be the start of an unexpected life path.

This week's research roundup feature: Gene fusions involving tumor protein p63 gene (TP63) occur in multiple T and B cell lymphomas and portend a dismal prognosis for patients. The function and mechanisms of TP63 fusions remain unclear, and there is no target therapy for patients with lymphoma harboring TP63 fusions. Here, we show that TP63 fusions act as bona fide oncogenes and are essential for fusion-positive lymphomas.

Mayo Clinic’s cardiac (CV) remote monitoring service uses the compact MoMe Kardia cardiac monitoring device that yields a continuous, 24/7 stream of a patient’s ECG and motion data, no matter their location. Any troubling or burgeoning events are observed virtually the moment they occur, allowing one of Mayo Clinic’s certified rhythm analysis technicians to intervene and facilitate care in near real time. And this is only the beginning; remote patient services are the way of the future, and the future is already here.

This week's research roundup feature: Semaglutide in HFpEF across obesity class and by body weight reduction.

This week's research roundup feature: There is a need to develop safe and effective pharmacologic options for the treatment of celiac disease (CeD); however, consensus on the appropriate design and configuration of randomized controlled trials (RCTs) in this population is lacking.

Outreach manager Jane Hermansen regards Mayo Clinic as the pinnacle of healthcare. Having spent her formative years in Minnesota, she was inspired by her uncle Roger to embark on a path as a laboratory scientist. Presently, she oversees the Mayo Clinic Laboratories outreach consulting and network programs. In addition, she spearheads the laboratory industry's only outreach conference, Leveraging the Laboratory.

This week's research roundup feature: Activated mast cells in periprosthetic joint infection-associated tissue.

An avid runner and fitness buff, Mark Kocak didn’t think he needed medication for his high cholesterol and hypertension. After coming to Mayo Clinic for ceramide testing, Mark knew exercise alone would not be enough to him on a path toward greater longevity.

This week's research roundup feature: 16S rRNA gene PCR/Sequencing of heart valves for diagnosis of infective endocarditis in routine clinical practice.

This week's research roundup feature: Association of plasma biomarkers of Alzheimer Disease with cognition and medical comorbidities in a biracial cohort.

This week's research roundup feature: Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis.

In spring of 2022, Adam Stewart joined Mayo Clinic’s Blood Donor Program as a marketing and recruitment coordinator. He enjoys and finds great purpose in his work because he loves to see members of his local community donate blood and help patients in need.

This week's research roundup feature: Age-based versus young-adult thresholds for nephrosclerosis on kidney biopsy and prognostic implications for CKD.