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Testing driven by
the Mayo Clinic
practice and research

A patient-centered, value-based approach to testing.

Our special coagulation laboratory has been at the forefront of patient-centered and value-based diagnostic laboratory testing, research, and patient management for nearly 90 years. Led by a multidisciplinary team of physicians, the laboratory offers a broad repertoire of coagulation tests covering a wide spectrum of bleeding and thrombosing disorders.

By The Numbers


profiles focusing on bleeding and
thrombosing disorders


esoteric coagulation test offerings available outside of the profile testing menu


special coagulation tests performed annually

An algorithmic and cost-effective
way of testing.

Coagulation-focused algorithms developed collaboratively among physicians, pathologists, laboratorians, and genetic counselors are available. These algorithms recommend approaches for diagnosis of specific diseases and assist in treatment and monitoring of patient care. In addition they can guide proper and cost-effective test utilization (e.g., activated protein C resistance testing with reflex to factor V Leiden analysis).

A Test in Focus

Rajiv Pruthi, M.B.B.S., gives an overview of the new coagulation NGS testing. He discusses when this testing should be ordered, how this testing compares to previous testing approaches, and what clinical action can be taken due to the results of this testing.

Additional Resources

Chromogenic factor VIII and IX assays: Impact on diagnosis and management of hemophilia

In this “Hot Topic,” Rajiv Pruthi, M.B.B.S., will discuss different types of hemophilia along with their pathologic basis. He will also cover various types of factor assays such as one stage and chromogenic factor assays for diagnosis and their role in management of hemophilia.

Test utilization practices for venous thromboembolism: a model of cost savings and efficiency at Mayo Clinic

A recent Mayo Clinic study has found that many U.S. health care providers are habitually ordering a mostly unnecessary, and quite expensive, genetic test to identify a patient’s hereditary risk of venous thromboembolism (VTE)

Preparation of platelet-poor plasma for special coagulation testing

In this "Hot Topic," Christopher Desens, MLS(ASCP) discusses the preparation of platelet-poor plasma for coagulation testing.