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Mayo Clinic Laboratories > Neurology

PUSHING THE BOUNDARIES OF NEUROLOGY DIAGNOSIS

Mayo Clinic Laboratories is leading an evolution in neurology testing. Propelled by ongoing discoveries of clinically relevant biomarkers, our laboratory scientists integrate research findings into test development and implementation. Collaboration between our labs and the clinical practice at Mayo Clinic supports development of clinically validated testing that delivers actionable answers for patients.

Eye on Innovation Phenotype-specific approach transcends traditional testing for autoimmune neurological conditions
Diagnostics in Practice Multiple sclerosis: Diagnostic criteria update and kappa free light chain testing
Microlearning Autoimmune Encephalitis Misdiagnosis
Patient Spotlight A Mayo Pathologist’s Journey through Paraneoplastic Syndrome and a Double Lung Transplant: Dr. Brad Karon
Webinar Pediatric Autoimmune Neurologic Disorders

NEUROLOGY TEST SPECIALTIES

Autoimmune disorders Autoimmune disorders
Autoimmune disorders

Covering the spectrum of autoimmune neurological disorders, our evaluations apply a phenotype-specific approach to diagnose and guide treatment for patients affected by immune-mediated neurological illness.

Biopharma testing Biopharma testing
Biopharma testing

With 19 subspecialty labs that perform neurology testing, we are at the forefront of research that integrates novel biomarker discoveries into our evaluations. Our menu, including testing for Alzheimer’s disease, dementia, and autoimmune conditions, provides partners with results that move solutions through the development pipeline.

Demyelinating disease Demyelinating disease
demyelinating disease

We offer sensitive and specific testing to diagnose a range of demyelinating diseases, from classic multiple sclerosis (MS) to atypical MS, AQP4/MOG-associated disorders, and spinal cord disorders.

Dementia Dementia
Dementia

Offering the industry’s most sophisticated suite of testing available, including biomarker evaluations, autoimmune panels, testing for rapidly progressive cases, and an innovative combination assay, Mayo Clinic Laboratories is a one-stop laboratory solution for dementia and Alzheimer’s disease testing.

Epilepsy Epilepsy
Epilepsy

We offer testing that identifies genetic and autoimmune causes of epilepsy. With testing developed by neurologists, epileptologists, and geneticists, physicians can determine the causes of epilepsy in their patients and identify potential treatment options.

Movement disorders Movement disorders
Movement disorders

Our comprehensive movement disorder testing includes an autoimmune movement disorders panel that contains the latest newly discovered clinically actionable antibodies. We also offer hereditary movement disorders testing that covers ataxia, Huntington's disease, Parkinson's disease, and more.  

Neurogenetics Neurogenetics
Neurogenetics

A multidisciplinary team of clinical neurology experts, laboratory scientists, and genetic counselors work collaboratively to develop and implement our neurogenetic testing. Covering the full range of neurogenetic illness, our testing is unparalleled in scope and detail and uses an algorithmic and phenotypic approach that ensures the right patient receives the right test at the right time.

Neuromuscular disorders Neuromuscular disorders
Neuromuscular disorders

Our comprehensive menu of precision testing enables physicians to diagnose and manage patients with disorders such as myasthenia gravis, Lambert-Eaton syndrome, immune-mediated necrotizing myopathy, hereditary myopathy, and more.

Pediatrics Pediatrics
Pediatrics

Including evaluations for autoimmune central nervous system disorders, multiple sclerosis, and narcolepsy, our data-driven pediatric testing provides precision results to guide treatment and place young patients on the path to healing.

Peripheral neuropathy Peripheral neuropathy
Peripheral neuropathy

We offer testing to identify peripheral autoimmune neuropathy with axonal or demyelinating causes, as well as next-generation sequencing to help establish whether a peripheral neuropathy is genetic in nature.

“The ability of Mayo Clinic to make discoveries and translate these into solutions for our patients is critical to our mission.”

John Mills, Ph.D., co-director, Neuroimmunology Laboratory

OUR DIFFERENCE

Clinically driven neurology test menu
Consolidate more of your sendout testing to one trusted lab.

Solving the most complex neurologic cases
We continually innovate to develop new testing approaches that enable answers to the rarest and most complex neurological conditions.

Backed by the world’s leading experts
Our laboratories are led by clinical neurologists who have extensive experience using testing to guide and directly impact patient care. These experts interpret each evaluation, providing clinically actionable answers, not just results.

News and updates

The latest

Using CSF testing to confirm autoimmune GFAP meningoencephalomyelitis featured image
Using CSF testing to confirm autoimmune GFAP meningoencephalomyelitis

Learn how our autoimmune/paraneoplastic evaluation for encephalopathy uses CSF testing to confirm an autoimmune GFAP meningoencephalomyelitis diagnosis.

Learn more
Living with ultra-rare epilepsy and chasing her dream: Giana Urse

Supported by Mayo Clinic’s holistic, precision medicine approach, which included advanced genetic insights, access to an emerging therapy, and tailored treatment monitoring, Giana Urse gained the confidence and clarity she needed to pursue her dream of becoming a dog trainer.

Using CSF testing to confirm autoimmune GFAP meningoencephalomyelitis

Learn how our autoimmune/paraneoplastic evaluation for encephalopathy uses CSF testing to confirm an autoimmune GFAP meningoencephalomyelitis diagnosis.

Autoimmune Encephalitis Misdiagnosis

Autoimmune encephalitis (AE) is a rare but serious condition, and accurate diagnosis is critical. Misdiagnosis can lead to unnecessary treatments, delayed care, and preventable complications.

Phenotype-specific approach transcends traditional testing for autoimmune neurological conditions

Autoimmune neurology testing has evolved beyond limited paraneoplastic evaluations to phenotype-specific panels that identify clinically relevant antibodies. This phenotype-specific approach significantly improves diagnostic accuracy, reduces false positives, and helps guide faster, more personalized treatment for complex neurological diseases.

Testicular cancer-associated paraneoplastic encephalitis

Learn more about how our movement disorders testing can help diagnose testicular cancer-associated paraneoplastic encephalitis.

Sorbitol dehydrogenase (SORD) deficiency

Learn more about how our testing protocol is useful in the diagnosis of sorbitol dehydrogenase (SORD) deficiency.

Glycine receptor Ab as a marker of stiff-person syndrome spectrum disorder

Find out how we use glycine receptor Ab as a marker of stiff-person syndrome spectrum disorder.

Risk of false positives with AQP4 ELISA methodology

Learn more about the risks of false positives with AQP4 ELISA methodology in CNS demyelinating disease testing.

Treatable autoimmune encephalitis diagnosed with phenotype-specific evaluation

Learn how a phenotype-specific autoimmune neurology evaluation diagnosed a treatable autoimmune encephalitis condition that was missed with a traditional paraneoplastic evaluation.

Neurofascin 155 IgG4 antibodies, a specific marker of chronic inflammatory demyelinating polyradiculoneuropathy

Find out how our testing uses neurofascin 155 IgG4 antibodies as a specific marker of chronic inflammatory demyelinating polyradiculoneuropathy.

MOG-IgG as a marker of acute disseminated encephalomyelitis

Learn more about our CNS demyelinating disease testing through this case study focused on MOG-IgG as a marker of acute disseminated encephalomyelitis.

Autoimmune Neurology: Phenotype-Based Testing

This webinar will discuss how autoimmune neurology testing has changed with expanding antibody discovery and why a patient-first, phenotype-specific approach improves test selection and interpretation.

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