Mayo Clinic Laboratories > Hematology > FISH testing

FISH testing

View video Hematologic FISH testing through MCL: How to order

Specific results through streamlined testing

Our approach to fluorescence in situ hybridization (FISH) testing was designed to simplify the ordering process and provide appropriate testing to meet individual patient needs. Testing options for adult and pediatric patients are available by disease state, including only the most relevant genetic probes, while specified panels continue to provide flexibility to select probe offerings.

Acute myeloid leukemia Acute myeloid leukemia
Acute myeloid leukemia

Many myeloid neoplasms lack a clonal bone marrow cytogenetic finding at diagnosis (normal karyotype) but can be better characterized with the aid of a comprehensive gene mutation profile.

B-cell lymphoma B-cell lymphoma
B-cell lymphoma

FISH testing allows for the detection of abnormal genes associated with various chromosome translocations and inversions in B-cell lymphoma.

B-cell and T-cell acute lymphoblastic leukemia B-cell and T-cell acute lymphoblastic leukemia
B-cell and T-cell acute lymphoblastic leukemia

Our fluorescence in situ hybridization (FISH) testing is designed to simplify the ordering process by providing diagnostic panels that include all appropriate genes.

Children’s Oncology Group Children’s Oncology Group
Children’s Oncology Group

Our Cytogenetics Laboratory is one of the longest-standing Children’s Oncology Group (COG)-approved laboratories in the world. Our team is committed to meeting the specific needs of COG patients and has developed one of the largest COG-specific testing menus to do just that.

Chronic lymphocytic leukemia Chronic lymphocytic leukemia
Chronic lymphocytic leukemia

Our approach to chronic lymphocytic leukemia testing meets all testing recommendations as well as comprehensive fluorescence in situ hybridization (FISH) panels, which detect for genetic biomarkers associated with disease severity, progression, and treatment response.

Eosinophilia Eosinophilia
Eosinophilia

Our suite of fluorescence in situ hybridization tests is designed to identify malignancies in select genes associated with eosinophilia.

Myelodysplastic syndrome Myelodysplastic syndrome
Myelodysplastic syndrome

Our approach to myelodysplastic syndrome (MDS) testing utilizes comprehensive fluorescence in situ hybridization (FISH) panels to detect for genetic biomarkers associated with disease severity, progression, and treatment response.

Plasma cell neoplasms Plasma cell neoplasms
Plasma cell neoplasms

Our approach to fluorescence in-situ hybridization (FISH) testing takes into account the fact that multiple myeloma is increasingly recognized as more than one disease, and is characterized by cytogenetic, molecular, and proliferative heterogeneity.

T-cell lymphoma T-cell lymphoma
T-cell lymphoma

We offer comprehensive fluorescence in situ hybridization (FISH) panels, as well as extensive immunohistochemistry (IHC) offerings, to diagnose and monitor T-cell lymphoma.

A specialized approach

  • Panels tailored to disease state and demographics to meet individual patient needs, as well as specific testing options for diagnosis vs. follow-up monitoring.
  • Thoughtfully crafted panels to promote utilization management and avoid over- or under-ordering of applicable tests.
  • Confidence that patients receive the right test the first time.
  • Simplified ordering processes with increased understanding of testing performed.
  • Alignment with testing recommendations by the National Comprehensive Cancer Network (NCCN) and the CLL-International Prognostic Index (CLL-IPI).
Resources
Download FISH Hematology test menu
View now FISH probe and panel project: An overview
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