Mayo Clinic researchers conducted a recent study in Gastroenterology to investigate whether gut-derived murine stem cells for interstitial cells of Cajal could mitigate experimental colitis.
Renal cell carcinoma (RCC) with rhabdoid differentiation is thought to portend a poor prognosis, similar to RCC with sarcomatoid differentiation. Mayo Clinic researchers reviewed a large series of patients with grade 4 RCC to determine the differential effects of rhabdoid and sarcomatoid differentiation on patient outcome.
Measurement of sex steroids, particularly testosterone and estradiol, is important for diagnosis or management of a host of conditions. Mayo Clinic researchers summarize why and how liquid chromatography tandem mass spectrometry (LC-MS/MS) is increasingly replacing other methodologies for measurement of testosterone and estradiol.
Detection of Histoplasma capsulatum urine antigen (UAg) is among the most sensitive and rapid means to diagnose histoplasmosis. In a recent study published in the Journal of Clinical Microbiology, Mayo Clinic researchers analyzed the IMMY analyte specific reagents for detection of Histoplasma galactomannan.
Mayo Clinic researchers conducted a study published in the American Journal of Gastroenterology, to determine whether patients with multifocal polysomy are more likely to manifest cholangiocarcinoma compared with patients with other chromosomal abnormalities, including unifocal polysomy and other FISH subtypes.
A recent study in Clinical Cancer Research, completed by Mayo Clinic researchers, examined tissue specimens at diagnosis from patients with follicular lymphoma that later transformed to define cell subtypes associated with transformation.
Mayo Clinic researchers, first author Ayalew Tefferi, M.D., in collaboration with the French consortium for CMML, conducted a study published in Leukemia to clarify the prognostic relevance of ASXL1 and SETBP1 mutations, among others, in World Health Organization-defined CMML and its added value to the Mayo prognostic model.
Coronary Microvascular Rarefaction and Myocardial Fibrosis in Heart Failure with Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is common and increasing in prevalence. Mayo Clinic researchers conducted a study in Circulation to test the hypothesis that cardiac hypertrophy, microvascular rarefaction and myocardial fibrosis are common and related in patients with HFpEF.
LDL cholesterol (LDL-C)3, an important modifiable risk factor for atherosclerotic cardiovascular disease, is primarily calculated via the Friedewald equation. However, a newly derived equation for LDL-C estimation was recently published that addressed limitations in the commonly used Friedewald LDL-C calculation method. Mayo Clinic researchers completed a study to evaluate the performance of a novel method to classify patients with superior concordance to measured LDL-C compared to the Friedewald method.
Mayo Clinic researchers completed a study in Modern Pathology to examine ERBB2 amplification and protein expression in micropapillary urothelial carcinoma and stage-matched typical urothelial carcinoma treated by radical cystectomy to assess the frequency of amplification and protein expression, and to determine the association with cancer-specific survival. Read this post to learn more.
Flow cytometry immunophenotyping has been suggested as an adjunctive technique in the evaluation of myeloid malignancies, especially in the myelodysplastic syndromes. Its use, however, has been limited due to complexity and cost restraints. A recent study by Mayo Clinic was completed to attempt a simpler approach to flow cytometry immunophenotyping in myeloid neoplasms.
The September issue of Fertility and Sterility highlights a recent study completed by Mayo Clinic's Dean Morbeck, Ph.D., Nikola Baumann, Ph.D., Dietrich Matern, M.D., Ph.D., and Thomas Moyer, Ph.D., designed to determine the composition of commercially available culture media and test whether differences in composition are biologically relevant in a murine model.
In a recent article in AACC, Elitza Theel, Ph.D., Director of the Infectious Disease Serology Laboratory at Mayo Clinic, and Matt Binnicker, Ph.D., Director of the Clinical Virology Laboratory in the Division of Clinical Microbiology at Mayo Clinic, review current syphilis assays and explain how laboratories can implement a new algorithm and advise clinicians.