Diagnostic Significance of Cell Kinetic Parameters in World Health Organization Type A and B3 Thymomas and Thymic Carcinomas
The prognostic importance of histologic classifications of thymic epithelial neoplasms is controversial. Evidence suggests that difficulties in reproducibility affect prognostic studies. A recent article in Human Pathology by Mayo Clinic, first author Anja Roden, M.D., addresses the diagnostic significant of cell kinetic parameters in type A or B3 thymoma and thymic carcinomas.
In the November issue of Clinical Biochemistry, Mayo Clinic researchers, first author Leslie Donato, Ph.D., conducted a study to assess the performance of two point of care (POC) devices for capillary lipid screening in fasting and post-prandial adults.
Short transverse myelitis is considered non-characteristic of neuromyelitis optica (NMO) spectrum disorders (NMOSDs). Mayo Clinic researchers conducted a study, recently published in Jama Neurology, to determine the frequency of short lesions at the initial myelitis manifestation of NMOSD and to compare the demographic, clinical, and radiological characteristics of aquaporin-4-IgG (AQP4-IgG) seropositive and seronegative STM.
Matrix Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF) MS for the Diagnosis of Infectious Diseases
Robin Patel, M.D., recently reviewed MALDI-TOF MS in Clinical Chemistry, providing a historical perspective on this new technology. MALDI-TOF MS is used as a tool for rapid, accurate, and cost-effective identification of cultured bacteria and fungi in clinical microbiology.
Central nervous system infection due to herpes simplex virus (HSV) is a medical emergency and requires a rapid diagnosis and initiation of therapy. A recent study published in the Journal of Clinical Microbiology by Matthew Binnicker, Ph.D., Mark Espy, and Cole Irish, compared a routine real-time PCR assay for HSV type 1 (HSV-1) and HSV-2 to a recently FDA-approved direct PCR assay using cerebrospinal fluid samples.
GenomeDx Biosciences today announced that the company has expanded its research agreement with Mayo Clinic to initiate a validation study to expand the use of the Decipher® Prostate Cancer Classifier, a genomic test capable of predicting metastatic prostate cancer, for use in prostate biopsy specimens.
Anticoagulation protocols used during mechanical circulatory support call for titration of antiplatelet agents. A recent study published in Clinical Chemistry by Mayo Clinic representatives compared the precision and reliability of five platelet function tests in healthy volunteers and donors on daily antiplatelet therapy to distinguish their efficacy for titrating antiplatelet therapy.
Usefulness of a Thyroglobulin Liquid Chromatography-Tandem Mass Spectrometry Assay for Evaluation of Suspected Heterophile Interference
Mayo Clinic representatives Brian Netzel, Stefan Grebe, M.D., Ph.D., and Alicia Algeciras-Schimnich, Ph.D. authored the article, "Usefulness of a Thyroglobulin Liquid Chromatography–Tandem Mass Spectrometry Assay for Evaluation of Suspected Heterophile Interference," in the July issue of Clinical Chemistry to describe their study which determined whether Tg measurement by LC-MS/MS would allow accurate quantification in samples with suspected HAB interference.
As of Aug. 22, there have been over 2600 suspected or confirmed cases of Ebola hemorrhagic fever. Of these cases, two adult United States nationals were admitted to Emory University Hospital in Atlanta, GA during the first week of August 2014 for treatment. To discuss their treatment, doctors of Emory Hospital authored the article, "Laboratory Test Support for Ebola Patients Within a High-Containment Facility," in American Society for Clinical Pathology's Lab Medicine Journal.
A recent article in The New York Times reported on celiac disease, an autoimmune disorder of the gut triggered by the gluten proteins in wheat and other grains, and its connection to the human brain. Upon analysis of several cases, treating an autoimmune disease of the gut (by avoiding gluten) resolved what looked like a debilitating disorder of the brain.
Evaluating Histologic Features to Distinguish Phyllodes Tumor From Cellular Fibroadenoma on Core Needle Biopsy Specimens
In the September issue of the American Journal of Clinical Pathology, Mayo Clinic's Saba Yasir, MBBS, Daniel Visscher, M.D., Sarah Jenkins, MS, and Aziza Nassar, M.D., conducted a study to evaluate histologic features that can help distinguish phyllodes tumor (PT) from cellular fibroadenoma (CFA) on core needle biopsy (CNB) specimens.
European Hospital highlighted Mayo Clinic's Piero Rinaldo, M.D., Ph.D., for his discussion on how big data can help to avoid false positives in newborn screening, which he presented at the 2014 AACC Annual Meeting & Clinical Lab Expo in July.
The Dark Daily discusses why highlighting the contribution of pathology to the practice of medicine is an effective way to educate consumers, and learn about the history of certain developments, including the frozen sections technique which was pioneered at Mayo Clinic.