Advanced diagnostics, redefined
As the only hospital reference lab integrated with a world-renowned academic healthcare institution, Mayo Clinic Laboratories fuses diagnostic testing innovation with a 150-year history of patient-focused care. In that tradition, we advocate for delivering care as close to the patient as possible, offering a vast menu of esoteric and advanced assays that complements, rather than competes with, local care delivery.
Our proactive consultative approach helps hospital laboratories uncover their financial potential and improve profitability while keeping patient care as the focus. Through synergistic relationships, we equip lab teams and hospital executives with tailored tools and strategies to expand laboratory capabilities and improve efficiencies. This supports the growth of the lab, and the health system, into new areas of diagnostic care.
“Our business model and our mission are to support the local care of patients. We work with hospitals and hospital laboratories to help them insource testing they should to take care of their patients, and give them access to those more uncommon tests we're developing within our practice.”
William Morice II, M.D., Ph.D., President and CEO, Mayo Clinic Laboratories

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An order-entry, clinical decision support tool developed by physicians and scientists at Froedtert and the Medical College of Wisconsin (MCW) for clinicians within the healthcare system who order autoimmune and paraneoplastic antibody panels has significantly improved test utilization, resulting in a 28% reduction in monthly test volumes of impacted tests.
Tying together the expertise and curiosity of Mayo Clinic autoimmune neurology researchers with eager patients who have rare disease and are looking for answers, the innovative collaboration benefits both patients affected by MOGAD and scientists on the front lines of discovery.
Joe Mondloch and his wife Sue have existed in a grey area of uncertainty due to the unpredictable autoimmune neurological illness Joe has lived with for the last seven years. Rare, incurable, and debilitating, the newly classified disorder can be hard to manage. But thanks to information and direction provided by a rare disease advocacy group, the Mondlochs sought care at Mayo Clinic and received much more than answers.
In this episode of Mayo Clinic Laboratories’ “Leveraging the Laboratory” podcast, host Jane Hermansen, outreach manager at Mayo Clinic Laboratories, talks with outreach solutions strategists Ellen Dijkman Dulkes and Brianne Newton about industry trends. In the past year, the health care industry has faced many challenges, especially in the laboratory.
PACE / State of FLPresentation Recording Coming Soon This webinar highlights the effect on patient/employee satisfaction, laboratory operation costs, and patient expectations for a positive collection experience.
VEXAS syndrome is a severe autoinflammatory disease that results in a spectrum of rheumatologic and hematologic conditions. The underlying cause of newly identified VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome — somatic mutations in the UBA1 gene of blood cells — was discovered at the National Institutes of Health (NIH) in 2020. Within six months, Mayo Clinic Laboratories was able to add a UBA1 test to the MayoComplete panel, as the team simultaneously worked on a single gene assay to allow doctors to test specifically for UBA1 mutations to screen patients for VEXAS syndrome. The team opted for a droplet digital PCR test — a novel and highly accurate approach to testing for UBA1 gene mutations.
Managing a successful hospital-based laboratory in today’s economic climate requires leaders to anticipate challenges, navigate obstacles, and develop creative approaches to unusual circumstances. The Mayo Clinic Laboratories outreach team explains the top five current trends happening in the laboratory industry.
CT scans and hiatal/abdominal ultrasounds could not uncover why, whenever he ate steak, Joseph Ducaji experienced severe stomach problems, itchy hives, chills, and nausea. It took specialized testing from Mayo Clinic to unlock a little-known condition caused by a tick bite (and, no, it’s not Lyme disease).
In this episode of Mayo Clinic Laboratories’ “Leveraging the Laboratory” podcast, host Jane Hermansen, outreach manager at Mayo Clinic Laboratories, talks with outreach solutions strategists Ellen Dijkman Dulkes and Brianne Newton about key performance indicators (KPIs). KPIs for a laboratory department should include outreach-specific KPIs, which can be used to support process improvement efforts and communicate the value and success of an outreach program.
Key performance indicators (KPIs) should be a part of every laboratory’s quality improvement plan, and that includes outreach-specific KPI metrics. Financial, internal-facing, and client-facing KPIs for outreach programs help to create a scorecard that allows a laboratory to continuously monitor and enhance its service.
Since March 2019, Paul Jannetto, Ph.D., director of the Metals Laboratory at Mayo Clinic, along with his colleagues across the enterprise and his laboratory staff, have developed, validated, and implemented an artificial intelligence (AI)-augmented test with algorithms designed to interpret kidney stone FTIR spectra. With more than 90,000 kidney stones analyzed each year at Mayo Clinic, this new AI-assisted test has streamlined lab processes and improved patient care.
It’s been more than three years since a team of specialists and genetic testing by Mayo Clinic Laboratories helped pinpoint the cause of Alexa Lofaro’s failing health. And today, she says she continues to feel “so much better” than she did when she first came to Mayo Clinic.
Almost four years ago, Mayo Clinic launched the Digital Pathology Program, a major pathology initiative. Phase 2 of this multi-phase rollout has recently been completed, which involved the implementation of cutting-edge digital equipment and software, and converting glass slides of patient samples into digital images. The conversion enables pathologists and laboratory technologists to view, store, retrieve, and share medical images more universally, without waiting for glass slides to be retrieved and delivered. This has significantly improved patient care because pathologists can now discuss cases with clinicians and surgeons in real time.