Advanced diagnostics, redefined
As the only hospital reference lab integrated with a world-renowned academic healthcare institution, Mayo Clinic Laboratories fuses diagnostic testing innovation with a 150-year history of patient-focused care. In that tradition, we advocate for delivering care as close to the patient as possible, offering a vast menu of esoteric and advanced assays that complements, rather than competes with, local care delivery.
Our proactive consultative approach helps hospital laboratories uncover their financial potential and improve profitability while keeping patient care as the focus. Through synergistic relationships, we equip lab teams and hospital executives with tailored tools and strategies to expand laboratory capabilities and improve efficiencies. This supports the growth of the lab, and the health system, into new areas of diagnostic care.
“Our business model and our mission are to support the local care of patients. We work with hospitals and hospital laboratories to help them insource testing they should to take care of their patients, and give them access to those more uncommon tests we're developing within our practice.”
William Morice II, M.D., Ph.D., President and CEO, Mayo Clinic Laboratories

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An order-entry, clinical decision support tool developed by physicians and scientists at Froedtert and the Medical College of Wisconsin (MCW) for clinicians within the healthcare system who order autoimmune and paraneoplastic antibody panels has significantly improved test utilization, resulting in a 28% reduction in monthly test volumes of impacted tests.
Lying in an ICU bed as sick as he could get, Jon Bratsch thought he was past the point of no return. But when a Mayo Clinic Laboratories’ test revealed the source of his dire symptoms, everything changed. Today, Jon’s back to the life and family he loves.
A tenacious fighter, Joy Carol never lost hope that a mysterious condition that had stripped her of her ability to move would be identified. Hope turned into reality when a Mayo Clinic Laboratories test identified the cause of her illness and opened the door to successful treatment.
To safeguard patient samples, staff in Mayo Clinic’s Histology Laboratory devised an inventive way to ensure that none of the paraffin-embedded blocks processed in the lab ever ends up in the trash.
Mayo Clinic Laboratories’ comprehensive approach to targeted antibody testing played a crucial and lifesaving role in moving Sheila Lewis to recovery from autoimmune encephalitis.
December 10, 2021 The laboratory industry is breathing a sigh of relief with the passage of S. 610, the Protecting Medicare and American Farmers from Sequester[...]
The quest to create a test pinpointing the source of the rare, testicular cancer-associated illness successfully concluded in the summer of 2021.
While Gregor Heinrich never could have imagined that testicular cancer was related to his problems with his vision and gait, learning he was positive for KLHL11 protein biomarkers meant he could receive treatment for both the cancer and the illness behind it.
November 19, 2021 From October 27 – 29, 2021, the American Society of Clinical Pathologists hosted a concurrent LIVE and Virtual conference. The folks who[...]
As chair of Mayo Clinic’s new Division of Computational Pathology and AI in the Department of Laboratory Medicine and Pathology, Jason Hipp, M.D., Ph.D., is eager to employ the most innovative tools available to benefit patients around the globe.
Advanced testing at Mayo Clinic Laboratories that confirmed a diagnosis of myasthenia gravis put Lorinda McKinley on the road to renewed health after she nearly lost it all to the rare autoimmune disease.
October 26, 2021 On September 27-28, 2021, Mayo Clinic Laboratories held its 32nd Leveraging the Laboratory conference, virtually. Attendees gave resounding positive feedback regarding content[...]
In a newly published study, a team from Mayo Clinic’s Advanced Diagnostics Laboratory has developed a mass spectrometry-based assay that’s able to detect COVID-19 (SARS-CoV-2) pathogens from human proteins with, remarkably, 98% sensitivity and 100% specificity. This is the first assay of its kind that can detect viral antigens “directly from clinical specimens” such as nasopharyngeal swabs. Mass spectrometry is a sensitive technique used to detect, identify, and quantitate molecules present in a sample.