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Mayo Clinic Laboratories > Hematology

Advancing the diagnosis of hematologic disorders

Our comprehensive test menu has been created to aid in diagnosis and treatment selection across the full spectrum of hematologic disorders. We have developed and validated practice-based, data-driven algorithms that improve patient care, increase efficiency, and reduce costs. Our hematology experts continuously drive innovation in laboratory testing, developing new approaches and using new technology to address patient needs they see every day in clinical practice.

Learn more Mayo Clinic MASSFIX quantitative testing
View now Hematology, oncology, and hereditary test selection guide
Answers from the Lab Assay provides quick diagnosis of VEXAS syndrome
Answers from the Lab Assay enhances and simplifies M-proteins screening

HEMATOLOGY TEST SPECIALTIES

Biopharma testing Biopharma testing
Biopharma testing

Our menu features diagnostic, prognostic, and monitoring assays across the spectrum of hematological disorders. From state-of-the-art MALDI-TOF mass spectrometry (Mayo Clinic MASSFIX) evaluations to comprehensive fluorescence in-situ hybridization (FISH) panels, our assays support and expedite clinical trials and drug development.

Coagulation disorders Coagulation disorders
Coagulation disorders

Our Special Coagulation Laboratory has been at the forefront of patient-centered and value-based diagnostic laboratory testing, research, and patient management for nearly 90 years. The laboratory offers a broad repertoire of coagulation tests covering a wide spectrum of bleeding, thrombosing, and platelet disorders.

Lymphoid neoplasms Lymphoid neoplasms
Lymphoid neoplasms

To assist clinicians with lymphoma diagnosis, Mayo Clinic has a highly experienced, nine-member hematopathology section focusing on lymphoma diagnosis, which diagnoses more than 3,000 lymphoma cases per year.

MayoComplete next-generation sequencing MayoComplete next-generation sequencing
MayoComplete next-generation sequencing

Our menu of MayoComplete next-generation sequencing assays includes targeted testing for a growing list of hematologic cancers. Utilizing next-generation sequencing, our MayoComplete testing ensures each patient receives personalized answers to guide their care.

Myeloid neoplasms Myeloid neoplasms
Myeloid neoplasms

Our leukemia test menu includes flow cytometry, chromosome, FISH, and molecular testing. We provide accurate results and expert interpretation from a highly focused team of laboratory specialists.

Pediatric Pediatric
Pediatric

Mayo Clinic Laboratories’ pediatric hematology testing was developed by a team of multidisciplinary experts and built around the needs of young patients to provide accurate answers that inform diagnosis and treatment selection.

Plasma cell neoplasms Plasma cell neoplasms
Plasma cell neoplasms

Our algorithmic approach ensures that the right tests are ordered at the right time, and that healthcare providers get clinically actionable answers for their patients faster.

Red blood cell disorders Red blood cell disorders
Red Blood Cell Disorders

Our Metabolic Hematology Laboratory is dedicated to providing accurate diagnoses and clinical interpretations for patients. For hematologists whose patients require only a single test, many components of our specialized can be ordered individually.

“We’re able to collaborate and hopefully contribute to patient care in a significant way, helping to establish standards for patients all over the world that may end up being diagnosed with this disease.”

David Viswanatha, M.D., co-director of the Molecular Hematopathology Laboratory

Our difference

Innovation and collaboration between experts
Our laboratories are led by board-certified hematopathologists who focus on molecular diagnostics and prognostics of hematologic disorders, reviewing cases to provide interpretation of results related to clinically relevant genes.

The right test at the right time
More than 30 hematology-focused algorithms are integrated directly into our testing approaches to simplify the ordering process and arrive at clinically actionable answers for your patients, faster.

Unparalleled service
Our testing is supported by expert laboratory directors and genetic counselors who assist with everything from test ordering to results interpretation and collaborate closely with clients to reach the right answers for patients.

News and updates

The latest

Keynote speakers set for 2025 Classical Hematology Conference featured image
Keynote speakers set for 2025 Classical Hematology Conference

At this year's Classical Hematology Conference we will be joined by Hematology experts, Adam Cuker, M.D. and Stephan Moll, M.D. Reserve your spot today.

Learn more
Preparation of Platelet-Poor Plasma for Special Coagulation Testing

In this months "Hot Topic," Christopher Desens, MLS(ASCP) discusses the preparation of platelet-poor plasma for coagulation testing.

Myeloproliferative Neoplasm: Morphology, Molecular Updates and Cost-Effective Test Utilization

The diagnosis of Myeloproliferative Neoplasm (MPN) must include an integrated approach and combine the clinical findings with laboratory results. In our latest “Hot Topic,” Rong He, M.D., discusses the subclassification of MPNs and the use of JAK2, CALR, and MPL mutational analysis in diagnosis and prognosis.

Myeloid Blast and Maturation Assessment by Flow Cytometry (“MDS Flow”)

Flow cytometric immunophenotyping method can be useful in assessing myeloid dysmaturation. In this “Hot Topic,” Dragon Jevremovic, M.D., Ph.D., describes a new flow cytometric test to detect aberrant patterns of expression in the diagnosis of myelodysplastic syndrome.

Resources
Download Hematology test request form
View now Hematology, oncology, and hereditary test selection guide
Learn more Fluorescence in situ hybridization (FISH) testing 
Delivering specialized testing and consultative support for:
Learn more Commercial laboratories
Learn more Global healthcare
Learn more Hospitals and health systems

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