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Mayo Clinic Laboratories > Hematology

Advancing the diagnosis of hematologic disorders

Our comprehensive test menu has been created to aid in diagnosis and treatment selection across the full spectrum of hematologic disorders. We have developed and validated practice-based, data-driven algorithms that improve patient care, increase efficiency, and reduce costs. Our hematology experts continuously drive innovation in laboratory testing, developing new approaches and using new technology to address patient needs they see every day in clinical practice.

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Micorlearning Preparation of Platelet-Poor Plasma for Special Coagulation Testing
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Answers from the Lab Assay provides quick diagnosis of VEXAS syndrome

HEMATOLOGY TEST SPECIALTIES

Biopharma testing Biopharma testing
Biopharma testing

Our menu features diagnostic, prognostic, and monitoring assays across the spectrum of hematological disorders. From state-of-the-art MALDI-TOF mass spectrometry (Mayo Clinic MASSFIX) evaluations to comprehensive fluorescence in-situ hybridization (FISH) panels, our assays support and expedite clinical trials and drug development.

Coagulation disorders Coagulation disorders
Coagulation disorders

Our Special Coagulation Laboratory has been at the forefront of patient-centered and value-based diagnostic laboratory testing, research, and patient management for nearly 90 years. The laboratory offers a broad repertoire of coagulation tests covering a wide spectrum of bleeding, thrombosing, and platelet disorders.

Lymphoid neoplasms Lymphoid neoplasms
Lymphoid neoplasms

To assist clinicians with lymphoma diagnosis, Mayo Clinic has a highly experienced, nine-member hematopathology section focusing on lymphoma diagnosis, which diagnoses more than 3,000 lymphoma cases per year.

MayoComplete next-generation sequencing MayoComplete next-generation sequencing
MayoComplete next-generation sequencing

Our menu of MayoComplete next-generation sequencing assays includes targeted testing for a growing list of hematologic cancers. Utilizing next-generation sequencing, our MayoComplete testing ensures each patient receives personalized answers to guide their care.

Myeloid neoplasms Myeloid neoplasms
Myeloid neoplasms

Our leukemia test menu includes flow cytometry, chromosome, FISH, and molecular testing. We provide accurate results and expert interpretation from a highly focused team of laboratory specialists.

Pediatric Pediatric
Pediatric

Mayo Clinic Laboratories’ pediatric hematology testing was developed by a team of multidisciplinary experts and built around the needs of young patients to provide accurate answers that inform diagnosis and treatment selection.

Plasma cell neoplasms Plasma cell neoplasms
Plasma cell neoplasms

Our algorithmic approach ensures that the right tests are ordered at the right time, and that healthcare providers get clinically actionable answers for their patients faster.

Red blood cell disorders Red blood cell disorders
Red Blood Cell Disorders

Our Metabolic Hematology Laboratory is dedicated to providing accurate diagnoses and clinical interpretations for patients. For hematologists whose patients require only a single test, many components of our specialized can be ordered individually.

“We’re able to collaborate and hopefully contribute to patient care in a significant way, helping to establish standards for patients all over the world that may end up being diagnosed with this disease.”

David Viswanatha, M.D., co-director of the Molecular Hematopathology Laboratory

Our difference

Innovation and collaboration between experts
Our laboratories are led by board-certified hematopathologists who focus on molecular diagnostics and prognostics of hematologic disorders, reviewing cases to provide interpretation of results related to clinically relevant genes.

The right test at the right time
More than 30 hematology-focused algorithms are integrated directly into our testing approaches to simplify the ordering process and arrive at clinically actionable answers for your patients, faster.

Unparalleled service
Our testing is supported by expert laboratory directors and genetic counselors who assist with everything from test ordering to results interpretation and collaborate closely with clients to reach the right answers for patients.

News and updates

The latest

Reserve your spot today for the 2026 Classical Hematology Conference featured image
Reserve your spot today for the 2026 Classical Hematology Conference

We are excited to announce that registration is now open for the 2026 Mayo Clinic Classical Hematology Conference: Nonmalignant Hematology and Bleeding and Thrombotic Disorders.

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Resources
Download Hematology test request form
Download Hematopathology/Cytogenetics test request form
View now Hematology, oncology, and hereditary test selection guide
Learn more Fluorescence in situ hybridization (FISH) testing 
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