PathWays Case Studies: February 2018

​A six-year-old boy presented with fever and bone pain. He was found to have thrombocytopenia, anemia, and splenomegaly. MRI showed bone marrow abnormality. A hematologic malignancy was suspected. He had a bone marrow biopsy, which showed foamy histiocytes, consistent with Gaucher disease.

	Erin Conboy, M.D. Fellow, Clinical Biochemical Genetics Mayo Clinic
	Silvia Tortorelli, M.D., Ph.D. Consultant, Division of Laboratory Genetics and Genomics Mayo Clinic Assistant Professor of Laboratory Medicine and Pathology Mayo Clinic College of Medicine

​This is a 19-year-old female with microcytic anemia. A colonoscopy revealed a polyp in the descending colon. After the procedure, she developed fever, and a Monospot test resulted positive.

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	Valeria Dal Zotto, M.D. Fellow, Surgical Pathology Mayo Clinic
	Rebecca L. King, M.D. Consultant, Division of Hematopathology Mayo Clinic Assistant Professor of Laboratory Medicine and Pathology Mayo Clinic College of Medicine

​A 36-year-old male presented to the clinic for routine warfarin monitoring. Blood was drawn for prothrombin time testing. In the lab, a medical technologist noted that the volume of packed red cells appeared higher than normal. The estimated hematocrit value was 57% (reference interval = 38.8% - 50.0%). A review of past hematology results for the patient showed that his hematocrit had been increasing over the past nine months.

Kendall Cradic, Ph.D. Fellow, Clinical Chemistry Mayo Clinic Assistant Professor of Laboratory Medicine and Pathology Mayo Clinic College of Medicine

Nikola Baumann, Ph.D. Consultant, Clinical Core Laboratory Services Mayo Clinic Assistant Professor of Laboratory Medicine and Pathology Mayo Clinic College of Medicine