October 2018 — Clinical Pathology

A 52-year-old female presented to the emergency department with chest discomfort. Cardiac troponin I (TnI), measured using a goat antibody-based sandwich immunoassay (ADVIA Centaur, Siemens Healthcare Diagnostics), was 9.22ng/mL (reference interval: ≤0.04ng/mL). Follow-up testing included troponinT (TnT) measurement of 0.02 ng/mL (reference interval: ≤0.01ng/mL) using a mouse antibody and biotin/streptavidin-based sandwich immunoassay from Roche Diagnostics, Inc (Elecsys). Because of discrepant cardiac troponin concentrations, the physician contacted the laboratory director. The laboratory investigated for assay interference with results displayed in tables below.

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Katherine Turner, Ph.D.
Fellow, Clinical Chemistry
Mayo Clinic
Nikola Baumann, Ph.D.
Consultant, Clinical Core Laboratory Services
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

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