Mass Spectrometry Applications for Monoclonal Antibody Therapeutics

By Kelley Luedke • December 3, 2018

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Maria Alice Willrich, Ph.D., Consultant in the Department of Laboratory Medicine and Pathology, and Paula Ladwig, Development Tech Coordinator at Mayo Clinic in Rochester, Minnesota, authored an article in Clinical Laboratory News on mass spectrometry applications for monoclonal antibody therapeutics.

In the article, Dr. Willrich and Ms. Ladwig discuss different applications of mass spectrometry in analyzing t-mAbs, including strategies for sample enrichment, quantitation, and detection, as well as internal standard requirements.

According to Dr. Willrich and Ms. Ladwig, "While assessing for t-mAbs is not a one-size-fits-all approach, mass spectrometry has proven to be a versatile technique capable of multitasking. With a triple quad or a quadrupole time-of-flight, a clinical laboratory could perform testing for differentiation between a t-mAb and a disease-causing clone, as well as quantitation of t-mAbs that require therapeutic drug monitoring for improved patient outcomes."

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.