Mass Spectrometry Applications for Monoclonal Antibody Therapeutics
Maria Alice Willrich, Ph.D., Consultant in the Department of Laboratory Medicine and Pathology, and Paula Ladwig, Development Tech Coordinator at Mayo Clinic in Rochester, Minnesota, authored an article in Clinical Laboratory News on mass spectrometry applications for monoclonal antibody therapeutics.
In the article, Dr. Willrich and Ms. Ladwig discuss different applications of mass spectrometry in analyzing t-mAbs, including strategies for sample enrichment, quantitation, and detection, as well as internal standard requirements.
According to Dr. Willrich and Ms. Ladwig, "While assessing for t-mAbs is not a one-size-fits-all approach, mass spectrometry has proven to be a versatile technique capable of multitasking. With a triple quad or a quadrupole time-of-flight, a clinical laboratory could perform testing for differentiation between a t-mAb and a disease-causing clone, as well as quantitation of t-mAbs that require therapeutic drug monitoring for improved patient outcomes."