Anatomic and Clinical Pathology

A 60-year-old man presented with a slow-growing non-painful 4.5 cm mass of the left parotid gland and underwent surgical excision. Below is an hematoxylin and eosin (H&E) section from the periphery of the lesion.

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Kyriakos Chatzopoulos, M.D.
Resident, Anatomic and Clinical Pathology
Mayo Clinic
Joaquin Garcia, M.D.
Consultant, Anatomic Pathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

Laboratory Genetics and Genomics

A 52-year-old male underwent whole-exome sequencing (WES) for amyotrophic lateral sclerosis (ALS). While no germline alterations relevant to his ALS were detected, multiple de novo mutations associated with hematological malignancy were unexpectedly discovered in ~20% of his sequencing reads, suggesting that these were somatic alterations. Review of the patient’s medical records revealed a persistently low white blood cell count. As a result of these incidental findings, a bone marrow biopsy was performed to assess for possible malignancy.

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Jaime Lopes, Ph.D.
Resident, Laboratory Genetics and Genomics
Mayo Clinic
Linda Hasadsri, M.D., Ph.D.
Consultant, Lab Genetics/Genomics
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

Pathology and Cytology

A 45-year-old woman presented with a 6 cm nodule in the upper arm. She had removed a bona fide lipoma from the same area >10 years ago. An MRI showed a suspected sarcoma and the lesion was excised.

HE1_FH_2018-11-22: Pushing border infiltration in the subcutaneous fat.
HE2_FH_2018-11-22: Areas with myxoid stroma
HE3_FH_2018-11-22: Areas with fibrous stroma
MUC4_FH-2018-11-22: Positive immunoreactivity for MUC4
HE4_FE_20-12-20_low-resolution

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Felix Haglund, M.D., Ph.D.
Resident, Pathology and Cytology
Karolinska University Hospital
Karen Fritchie, M.D.
Consultant, Anatomic Pathology
Mayo Clinic
Associate Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine
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Michelle Odean

Michelle Odean, Editorial Assistant at Mayo Clinic Laboratories, supports internal and client-facing communications. Outside of work, she enjoys running, rock climbing, yoga, and snuggling with her two bunnies.