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February 2019 — Hematopathology

A 61 year old man with a 1.5 year history of eosinophilia (absolute eosinophil count up to 32x109) undergoes a third bone marrow biopsy. Prior laboratory studies to evaluate for the etiology of eosinophilia have been negative. The current specimen reveals absolute eosinophilia with cytologic atypia on peripheral smear and bone marrow aspirate, a hypercellular bone marrow with megakaryocyte atypia.  Blasts are not increased. Cytogenetics revealed 46 XY del(3)(q21 )[19/20].

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Andres Madrigal, M.D., Ph.D.
Resident, Hematopathology
Mayo Clinic
Min Shi, M.D., Ph.D.
Consultant, Hematopathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine
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