| Web: | mayocliniclabs.com |
|---|---|
| Email: | mcl@mayo.edu |
| Telephone: | 800-533-1710 |
| International: | +1 855-379-3115 |
| Values are valid only on day of printing | |
| Web: | mayocliniclabs.com |
|---|---|
| Email: | mcl@mayo.edu |
| Telephone: | 800-533-1710 |
| International: | +1 855-379-3115 |
| Values are valid only on day of printing | |
A 52-year-old man presented with right-sided upper and lower extremity weakness. He was previously diagnosed with HIV infection, though he is not currently on antiretroviral therapy. Brain MRIs demonstrated a T2-hyperintense, non-enhancing lesion within the left posterior frontal lobe, in the region of the motor cortex.
He subsequently underwent a brain biopsy.
 |
Kathryn Eschbacher, M.D. Resident, Anatomic Pathology/Neuropathology Mayo Clinic |
 |
Aditya Raghunathan, M.D., M.P.H. Consultant, Anatomic Pathology Mayo Clinic Assistant Professor of Laboratory Medicine and Pathology Mayo Clinic College of Medicine |
A 37-year-old G4P1212 patient presented to labor and delivery for preterm premature rupture of membranes (PPROM) at 25 3/7 weeks gestation. Prior to presentation, the patient’s pregnancy was uncomplicated. Immediately following rupture of membranes, the patient noticed a non-malodourous milky discharge. A bacterial urine culture was negative. The patient was afebrile, but due to fetal and maternal tachycardia, there was clinical concern for acute chorioamnionitis. Prenatal steroids and latency antibiotics (gentamicin and clindamycin) were administered, and a classical cesarean section was performed.
Macroscopic and microscopic evaluation of the placenta demonstrated the following findings:
 |
E. Heidi Cheek, M.H.S., PA(ASCP)CM Pathologists' Assistant Mayo Clinic Assistant Professor of Laboratory Medicine and Pathology Mayo Clinic College of Medicine |
 |
J. Kenneth Schoolmeester, M.D. Consultant, Anatomic Pathology Mayo Clinic Assistant Professor of Laboratory Medicine and Pathology Mayo Clinic College of Medicine |
A 72-year-old man with a history of chronic atrial fibrillation on warfarin anticoagulation and a questionable history of immune-mediated heparin-induced thrombocytopenia was admitted for elective abdominal surgery. His warfarin anticoagulation was bridged with argatroban in the peri-operative period. Two days after the procedure, a DIC/ICF profile was ordered due to a fall in platelet count and hematocrit and operative site oozing. The results of the coagulation laboratory studies are shown below.
| Test | Result | Units | Reference Range |
| Prothrombin time (PT) | 25.1 | sec | 10.3 – 12.8 |
| PT 1:1 mix | 14.5 | sec | 10.3 – 12.8 |
| Activated partial thromboplastin time (APTT) | 58 | sec | 26 - 36 |
| APTT 1:1 mix | 50 | sec | 26 - 36 |
| Dilute Russell viper venom time (DRVVT) screen ratio | 2.3 | ratio | 0.0 – 1.1 |
| DRVVT mix ratio | 2.0 | ratio | 0.0 – 1.1 |
| DRVVT confirm ratio | 0.9 | ratio | 0.0 – 1.1 |
| Thrombin time (TT) | 276 | sec | 15 - 23 |
| Reptilase time (RT) | 17 | sec | 14.0 – 23.9 |
| Clauss fibrinogen | 125 | mg/dL | 200 – 430 |
| PT-derived fibrinogen | 480 | mg/dL | 261 - 595 |
| D-dimer | 750 | D-dimer units (DDU) | 0 - 250 |
| Soluble fibrin monomer complexes (SFMC) | <8 | mcg/mL | 0.0 – 7.9 |
 |
Jansen Seheult, M.B., B.Ch., B.A.O. Resident, Special Coagulation Mayo Clinic |
 |
Nahla Heikal, M.D. Senior Associate Consultant, Hematopathology Mayo Clinic |
