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May 2019 — Anatomic and Clinical Pathology: Case 2

A 21-year-old man with a history of germ cell tumor status post orchiectomy, reported as a 7 cm mass; 80% yolk sac and 20% teratomatous, presented with a lesion in his left lung. The wedge resection revealed a 1.3 cm solid mass. The tumor contained a population of mononuclear cells with nuclear pleomorphism, and a population of larger multinucleated cells with smudged chromatin. Immunohistochemistry revealed immunoreactivity to hCG and GATA3 and no immunoreactivity to OCT3/4 and CD30.

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Photo of Sara Cook, M.D., Ph.D. Sara Cook, M.D., Ph.D.
Resident, Anatomic and Clinical Pathology
Mayo Clinic
Photo of Ruifeng (Ray) Guo, M.D., Ph.D. Ruifeng (Ray) Guo, M.D., Ph.D.
Senior Associate Consultant, Anatomic Pathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine
Photo of Loren Herrera Hernandez, M.D. Loren Herrera Hernandez, M.D.
Consultant, Anatomic Pathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine
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