May 2019 — Anatomic and Clinical Pathology: Case 2

By MCL Education • May 14, 2019

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A 21-year-old man with a history of germ cell tumor status post orchiectomy, reported as a 7 cm mass; 80% yolk sac and 20% teratomatous, presented with a lesion in his left lung. The wedge resection revealed a 1.3 cm solid mass. The tumor contained a population of mononuclear cells with nuclear pleomorphism, and a population of larger multinucleated cells with smudged chromatin. Immunohistochemistry revealed immunoreactivity to hCG and GATA3 and no immunoreactivity to OCT3/4 and CD30.

	Sara Cook, M.D., Ph.D. Resident, Anatomic and Clinical Pathology Mayo Clinic
	Ruifeng (Ray) Guo, M.D., Ph.D. Senior Associate Consultant, Anatomic Pathology Mayo Clinic Assistant Professor of Laboratory Medicine and Pathology Mayo Clinic College of Medicine
	Loren Herrera Hernandez, M.D. Consultant, Anatomic Pathology Mayo Clinic Assistant Professor of Laboratory Medicine and Pathology Mayo Clinic College of Medicine

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