Bone and Soft Tissue Pathology

40 year old woman with a 3 cm intraabdominal mass, attached to peritoneum.

STAT6
CD34

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Photo of Nooshin Karamzadeh Dashti, M.D., M.P.H. Nooshin Karamzadeh Dashti, M.D., M.P.H.
Fellow, Bone and Soft Tissue Pathology
Mayo Clinic
Photot of Gary L. Keeney, M.D. Gary Keeney, M.D.
Consultant, Anatomic Pathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

Surgical Pathology

41-year-old man with familial adenomatous polyposis syndrome presented with a 1.8 cm solid nodule of the right thyroid lobe.

Beta catenin
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Photo of Jordan Eldersveld, D.O. Jordan M. Eldersveld, D.O.
Fellow, Surgical Pathology
Mayo Clinic
Photo of Jorge Torres-Mora, M.D. Jorge Torres-Mora, M.D.
Consultant, Anatomic Pathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

Hematopathology

A 59-year-old female presents with hypersplenism. CT scan showed multiple hypo-attenuating nodules in the spleen. The patient underwent splenectomy.

CD8
CD68

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Photo of Khadijeh Jahanseir, M.D. Khadijeh Jahanseir, M.D.
Resident, Anatomic and Clinical Pathology
Mayo Clinic
Photo of William Macon, M.D. William Macon, M.D.
Consultant, Hematopathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

Clinical Pathology

A 13-month-old female underwent an allogeneic liver transplant at 3-months of age for end stage liver failure secondary to gestational allo-immune liver disease. Eight months following the transplant, the patient was found to have elevated liver transaminases, hyperbilirubinemia, leukocytosis along with itching and worsening skin rash indicating allograft rejection. Susequent liver biopsies displayed cholestasis features and ductopenic chronic rejection. Measured total serum cholesterol was found to be elevated at 1006 mg/dL. Clinical service then requested a complete lipid profile metabolic analysis.

Figure 1
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Abdulrahman Saadalla, M.B., B.Ch.
Resident, Clinical Pathology
Mayo Clinic
Leslie Donato, Ph.D.
Consultant, Clinical Core Laboratory Services
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

Genitourinary Pathology

A 62 year old female presented with a 6 cm left renal cortical mass. She underwent a left radical nephrectomy and photomicrographs of the lesion are shown below.

H&E, 40x
H&E, 100x
H&E, 100x
H&E, 200x

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Photo of Rafael E. Jimenez, M.D. Benjamin Van Treeck, M.D.
Resident, Anatomic and Clinical Pathology
Mayo Clinic
Photo of Rafael E. Jimenez, M.D. Rafael Jimenez, M.D.
Consultant, Anatomic Pathology
Mayo Clinic
Associate Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

Laboratory Genetics and Genomics

A 28-year-old male was referred to the Cytogenetics laboratory due to a history of a partner with multiple miscarriages. Chromosome analysis of peripheral blood revealed a normal karyotype 46,XY (Figure 1), but nine metaphases also showed gaps at 16q23 (Figure 2).

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Photo of Cinthya Zepeda Mendoza, Ph.D. Cinthya Jeanette Zepeda Mendoza, Ph.D..
Fellow, Laboratory Genetics and Genomics
Mayo Clinic
Photo of Ross Rowsey, Ph.D. Ross Rowsey, Ph.D.
Senior Associate Consultant, Laboratory Genetics and Genomics
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine
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MCL Education

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