Transfusion Medicine

A 25-year-old man is a repeat whole blood donor and recently donated blood. Routine blood donor pathogen screening came back positive for human immunodifficiency virus-1 (HIV-1), which was confirmed by western blot and viral RNA quantitation assays. His previous donation attempt was five months ago and complicated by vasovagal reaction. That incomplete unit was discarded without testing. His previous donations were 11 months ago, 17 months ago, 22 months ago and 27 months ago were either negative or non-reactive for all required infectious disease screening tests.

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Aleh (Oleg) Bobr, M.D.
Fellow, Transfusion Medicine
Mayo Clinic
Photo of Dr. Justin Kreuter Justin Kreuter, M.D.
Consultant, Transfusion Medicine
Mayo Clinic
Instructor in Laboratory Medicine and Pathology
Mayo Clinic College of Medicine
@KreuterMD

Hematopathology

A seven-year-old female presents with a left cheek mass. Flow cytometric immunophenotyping showed an abnormal cell population that expressed CD2, CD4 (partial weak), CD7, CD38, CD45 (dim), CD56, CD11c, HLA-DR, and TdT. Representative images of the biopsy are shown. Immunohistochemical stains demonstrated the infiltrate was positive for CD123, TCL1A, and TdT. CD1a, CD3, CD20, MPO, and EBER were negative.

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Photo of Joanna Dalland, M.D. Joanna Dalland, M.D.
Fellow, Hematopathology
Mayo Clinic
Photo of Matthew (Matt) Howard, M.D. Matthew (Matt) Howard, M.D.
Consultant, Hematopathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

Bone and Soft Tissue Pathology -Case 1

A 12-year-old male presented with a destructive mass in distal femur.

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Photo of Nooshin Karamzadeh Dashti, M.D., M.P.H. Nooshin Karamzadeh Dashti, M.D., M.P.H.
Fellow, Bone and Soft Tissue Pathology
Mayo Clinic
Photo of Carrie Y. Inwards, M.D. Carrie Inwards, M.D.
Consultant, Anatomic Pathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

Bone and Soft Tissue Pathology -Case 2

72 year old male without any significant past medical history presented with right groin soft tissue mass, measuring 12 x 9 x 7 cm. There was no connection to the underlying bone, but the mass had ruptured anteriorly into the subcutaneous compartment of the anterior thigh. The tumor cells were positive for WT1 (strong, diffuse) and CD99 (patchy), and negative for  keratin, desmin, S100,  Melan A, HMB45, PAX5, MUM1, CD43, TLE-1 and OCT4.  SMARCB1 (INI-1) is reatained. Fluorescence in situ hybridization (FISH) studies failed to show EWSR1 rearrangement, and RT-PCR did not reveal EWSR1-FLI1 or EWSR1-ERG fusion transcripts.

H&E
H&E
CD99
WT-1

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Suvra Roy, M.B.B.S.
Fellow, Surgical Pathology
Mayo Clinic
Karen Fritchie, M.D.
Consultant, Anatomic Pathology
Mayo Clinic
Associate Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

Cardiovascular Pathology

A 50-year-old man who was known to have systemic hypertension developed sudden onset of severe back pain with associated diaphoresis. He lost consciousness approximately one hour after the onset of symptoms and, despite resuscitation attempts, died. An autopsy was conducted and he was found to have an acute aortic dissection originating just inferior to the left subclavian artery and extending to the iliac arteries (Stanford A/DeBakey IIIb). The following are microscopic sections of his left renal artery.

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Photo of Catherine Morris, M.D. Catherine Morris, M.D.
Fellow, Cardiovascular Pathology
Mayo Clinic
Photo of      Joseph J. Maleszewski, M.D.   Joseph Maleszewski, M.D.
Professor of Laboratory Medicine and Pathology
Professor of Medicine
Departments of Laboratory Medicine and Pathology, Cardiovascular Medicine, and Clinical Genomics
Mayo Clinic College of Medicine
@joemaleszewski

Clinical Chemistry

An 88-year old-female presented with chronic lymphocytic leukemia under chemotherapy.

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Vijayalakshmi Nandakumar, Ph.D., M.S.
Fellow, Clinical Chemistry
Mayo Clinic
Image of Brad S. Karon, M.D., Ph.D Brad Karon, M.D., Ph.D.
Consultant, Clinical Core Laboratory Services
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

Surgical Pathology

A 60-year-old patient presented for evaluation of an asymptomatic unilateral thyroid nodule that was detected during a dental exam. A thyroidectomy was performed. Gross examination identified a firm, unifocal lesion with areas of hemorrhage and calcification.

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Krasimira (Krasi) Rozenova, M.D., Ph.D.
Resident, Anatomic and Clinical Pathology
Mayo Clinic
J. Kenneth Schoolmeester, M.D.
Consultant, Anatomic Pathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

 

Genitourinary Pathology

46 year old female presented with a renal mass. Her past medical history was significant for depression/anxiety, type 2 diabetes, hyperlipidemia, thyroid problems. CT scan demonstrated a 2.8 cm solid enhancing renal mass. The patient underwent a partial nephrectomy. Grossly, the mass measured 2.9 x 2.4 x 2 cm and was confined to the kidney.

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Photo of Malvika Solanki, M.B.B.S., Ph.D. Malvika Solanki, M.B.B.S., Ph.D.
Fellow, Multidisciplinary Breast Pathology
Mayo Clinic
Photo of John Cheville, M.D. John Cheville, M.D.
Consultant, Anatomic and Clinical Pathology
Supervisor of Rearch Services-Anatomic and Clinical Pathology,
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine
mmledu

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This post was developed by our Education and Technical Publications Team.

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