September 2019 — Renal

A 68-year-old male with history of chronic lymphocytic leukemia presented with subnephrotic range proteinuria (protein/creatinine ratio of 2.5), hemoglobin (13.1 g/dl) and ESR of 50 mm/hour. Core needle biopsy was performed to assess his proteinuria. Representative images of the biopsy are shown. Immunohistochemistry staining was performed and showed positive CD 20, CD 5, and CD 23.

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Mazen Osman, M.B., B.Ch.
Resident, Anatomic and Clinical Pathology
Mayo Clinic
Joseph Grande, M.D., Ph.D.
Consultant, Anatomic Pathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Science

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