A 27-year-old man underwent amputation of the right fourth toe for a soft tissue mass.
This quiz is no longer available.Kyriakos Chatzopoulos, M.D. Resident, Anatomic and Clinical Pathology Mayo Clinic |
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Andrew Folpe, M.D. Consultant, Anatomic Pathology Mayo Clinic Professor of Laboratory Medicine and Pathology Mayo Clinic College of Medicine and Science |
Chimeric antigen receptor T cells (CAR T cells) represent an exciting new area of cellular therapy. Manufacturing autologous CAR T cells involves virally transducing a patient’s T cells to express a receptor to heighten recognition of tumor-specific antigens. From a regulatory standpoint, CAR T cells are subject to regulation both as a drug and as a biological product. This presents ongoing challenges for cellular therapy programs and laboratories that seek to develop in-house manufacturing of next-generation CAR T cell products.
This quiz is no longer available.Ashley Krull, Ph.D. Fellow, Cellular Therapy Mayo Clinic @AshleyAKrull |
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Allan Dietz, Ph.D. Consultant, Transfusion Medicine Mayo Clinic Associate Professor of Laboratory Medicine and Pathology Instructor in Biochemistry and Molecular Biology Mayo Clinic College of Medicine and Science |
A 19 year old female with a complex phenotype suggestive of a mitochondrial disorder had mitochondrial DNA sequencing performed three times at an outside institution, all with inconclusive results due to “multiple heteroplasmic positions”. Mitochondrial genome sequencing was performed here revealing 6 benign homoplasmic and 21 benign variants at 10-20% heteroplasmy. When variants are stratified by frequency, this patient appears to have two distinct haplogroups (Figs A-B). Normally individuals have only one haplogroup, which is maternally inherited.
This quiz is no longer available.Jaime Lopes, Ph.D. Fellow, Laboratory Genetics and Genomics Mayo Clinic |
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Linda Hasadsri, M.D., Ph.D. Consultant, Laboratory Genetics and Genomics Mayo Clinic Assistant Professor of Laboratory Medicine and Pathology Mayo Clinic College of Medicine and Science |
This is a surgical pathology case of a 70-year-old woman with multiple bilateral relatively stable lung nodules and history of metastatic leiomyosarcoma of Mullerian origin status post debulking 4 years ago. During frozen section the rectosigmoid resection and the liver biopsy showed involvement by leimyosarcoma. However, the lesion found on a lung wedge resection could only be described as a biphasic tumor. On permanet section this lesion’s findings are shown below.
This quiz is no longer available.Simone Barreto Siqueira Parrilha Terra, M.D. Resident, Cytopathology Mayo Clinic |
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Joanne (Eunhee) Yi, M.D. Consultant, Anatomic Pathology Mayo Clinic Professor of Laboratory Medicine and Pathology Mayo Clinic College of Medicine and Science |
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