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January 2020 — Bone and Soft Tissue & Surgical

A 27-year-old man underwent amputation of the right fourth toe for a soft tissue mass.

CLICK IMAGE TO SEE: Virtual Microscopy

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Photo of Kyriakos Chatzopoulos, M.D. Kyriakos Chatzopoulos, M.D.
Resident, Anatomic and Clinical Pathology
Mayo Clinic
Photo of Andrew Folpe, M.D. Andrew Folpe, M.D.
Consultant, Anatomic Pathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Science

January 2020 — Cellular Therapy

Chimeric antigen receptor T cells (CAR T cells) represent an exciting new area of cellular therapy. Manufacturing autologous CAR T cells involves virally transducing a patient’s T cells to express a receptor to heighten recognition of tumor-specific antigens. From a regulatory standpoint, CAR T cells are subject to regulation both as a drug and as a biological product. This presents ongoing challenges for cellular therapy programs and laboratories that seek to develop in-house manufacturing of next-generation CAR T cell products.

Image credit: National Cancer Institute

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Photo of Ashley A. Krull, Ph.D.   Ashley Krull, Ph.D.
Fellow, Cellular Therapy
Mayo Clinic
@AshleyAKrull
Photo of Allan B. Dietz, Ph.D. Allan Dietz, Ph.D.
Consultant, Transfusion Medicine
Mayo Clinic
Associate Professor of Laboratory Medicine and Pathology
Instructor in Biochemistry and Molecular Biology
Mayo Clinic College of Medicine and Science

January 2020 — Laboratory Genetics and Genomics

A 19 year old female with a complex phenotype suggestive of a mitochondrial disorder had mitochondrial DNA sequencing performed three times at an outside institution, all with inconclusive results due to “multiple heteroplasmic positions”. Mitochondrial genome sequencing was performed here revealing 6 benign homoplasmic and 21 benign variants at 10-20% heteroplasmy. When variants are stratified by frequency, this patient appears to have two distinct haplogroups (Figs A-B). Normally individuals have only one haplogroup, which is maternally inherited.

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Photo of Jaime L. Lopes, Ph.D. Jaime Lopes, Ph.D.
Fellow, Laboratory Genetics and Genomics
Mayo Clinic
Photo of Jaime Lopes, Ph.D. Fellow, Laboratory Genetics and Genomics Mayo Clinic Linda Hasadsri, M.D., Ph.D. Linda Hasadsri, M.D., Ph.D.
Consultant, Laboratory Genetics and Genomics
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Science

January 2020 — Pulmonary

This is a surgical pathology case of a 70-year-old woman with multiple bilateral relatively stable lung nodules and history of metastatic leiomyosarcoma of Mullerian origin status post debulking 4 years ago. During frozen section the rectosigmoid resection and the liver biopsy showed involvement by leimyosarcoma. However, the lesion found on a lung wedge resection could only be described as a biphasic tumor. On permanet section this lesion’s findings are shown below.

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Photo of Simone Barreto Siqueira Parrilha T, M.D.
Simone Barreto Siqueira Parrilha Terra, M.D.

Resident, Cytopathology
Mayo Clinic
Photo of Joanne (Eunhee) E. Yi, M.D. Joanne (Eunhee) Yi, M.D.
Consultant, Anatomic Pathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Science
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This post was developed by our Education and Technical Publications Team.