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February 2020 — Hematopathology

A 43-year-old female presents with seizures following weeks of progressive lower extremity numbness. Imaging reveals a contrast-enhancing parasagittal brain mass without other systemic findings. She underwent brain biopsy (see photomicrographs below). Additional immunohistochemical stains for CD30, ALK, and infection (toxoplasma, HSV, CMV, VZV, adenovirus) are negative. EBV in situ hybridization is negative. Clonal T-cell receptor gene rearrangement is detected by molecular analysis.

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Photo of Daniel (Dan) P. Larson, M.D.
Daniel (Dan) P. Larson, M.D.

Resident, Hematopathology
Mayo Clinic
William Macon, M.D.
Consultant, Hematopathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Science
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This post was developed by our Education and Technical Publications Team.