February 2020 — Hematopathology

By MCL Education • February 11, 2020

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A 43-year-old female presents with seizures following weeks of progressive lower extremity numbness. Imaging reveals a contrast-enhancing parasagittal brain mass without other systemic findings. She underwent brain biopsy (see photomicrographs below). Additional immunohistochemical stains for CD30, ALK, and infection (toxoplasma, HSV, CMV, VZV, adenovirus) are negative. EBV in situ hybridization is negative. Clonal T-cell receptor gene rearrangement is detected by molecular analysis.

	Daniel (Dan) P. Larson, M.D. Resident, Hematopathology Mayo Clinic
	William Macon, M.D. Consultant, Hematopathology Mayo Clinic Professor of Laboratory Medicine and Pathology Mayo Clinic College of Medicine and Science

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This post was developed by our Education and Technical Publications Team.